Development of Hypertension in Adolescents with Pre-Hypertension
Development of Hypertension in Adolescents with Pre-Hypertension
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DOI：
10.1016/j.jpeds.2011.07.010
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发表时间：
2012-01-01
影响因子：
5.1
通讯作者：
Samuels, Joshua
中科院分区：
文献类型：
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作者：
Redwine, Karen M.;Acosta, Alisa A.;Samuels, Joshua
目的是评估具有预急性前的青少年发生事件高血压（HTN）的风险。研究完成了从2000年至2007年参加多个学校血压（BP）筛查的学生进行的辅助分析。在每个屏幕上，高度，体重和2至4个bps在多达3次时测量了BP> = 95个百分位时。在初始屏幕上有确认的HTN的学生被排除在外，事件HTN被定义为BP> =第95个百分位数，在后来的屏幕的所有3次访问中。使用COX比例模型计算出发病率（IR）和危害比率（HR）。1006名学生的注册，HTN在11（IR 0.5％/年）中以2.1年的观察为11（IR 0.5％）。 IRS的“高风险”学生（高血压前或高血压较高，随访bp = BP = 90％的基线访问，6.6％/年HR 24.33（5.68-104.29）]。 2004年特遣部队定义的高血压也增加了1.1％/年（HR，2.98; 0.77-11.56）]。结论增加了BP的增加增加需要在青少年的有效策略中发展HTN的风险。
Objective To evaluate the risk for developing incident hypertension (HTN) in adolescents with pre-hypertension.Study design A secondary analysis of students participating in multiple school-based blood pressure (BP) screens from 2000 to 2007 was completed. At each screen, height, weight, and 2 to 4 BPs were measured on as many as 3 occasions when BP remained >= 95th percentile. Students with confirmed HTN at their initial screen were excluded, and incident HTN was defined as having a BP >= 95th percentile at all 3 visits of a later screen. Incidence rates (IR) and hazard ratios (HR) were calculated by using Cox Proportional models.Results Of 1006 students, HTN developed in 11 (IR 0.5%/year) in a mean of 2.1 years of observation. IRs were higher in "at-risk" students (pre-hypertensive or hypertensive with follow-up BP = 90th percentile at 3 baseline visits, 6.6%/year HR 24.33 (5.68-104.29)]. Although not significant, students with pre-hypertension by the 2004 Task Force definition also had an increased IR of 1.1%/year (HR, 2.98; 0.77-11.56)].Conclusion Elevated BP increases the risk for the development of HTN during adolescence. Effective strategies for preventing HTN in at-risk adolescents are needed. (J Pediatr 2012;160:98-103).