Reactive oxygen species in cell signaling.
Reactive oxygen species in cell signaling.
复制标题
DOI：
10.1152/ajplung.2000.279.6.l1005
复制
发表时间：
2000-12
期刊：
影响因子：
--
通讯作者：
V. Thannickal;B. Fanburg
中科院分区：
文献类型：
--
作者：
V. Thannickal;B. Fanburg
活性氧（ROS）是细胞代谢的副产物，主要在线粒体中产生。当细胞产生的ROS破坏其抗氧化能力时，可能会对细胞大分子如脂质、蛋白质和DNA造成损害。这种“氧化应激”状态被认为有助于许多人类疾病的发病机制，包括肺部疾病。最近的研究还表明，ROS是由生长因子和细胞因子在正常生理信号中产生的特殊质膜氧化酶产生的。在这篇综述中，我们研究了配体诱导的ROS产生的证据，其细胞来源，以及被激活的信号通路。新兴概念的信号转导机制的ROS，涉及细胞氧化还原状态和蛋白质的氧化修饰的改变也进行了讨论。
Reactive oxygen species (ROS) are generated as by-products of cellular metabolism, primarily in the mitochondria. When cellular production of ROS overwhelms its antioxidant capacity, damage to cellular macromolecules such as lipids, protein, and DNA may ensue. Such a state of "oxidative stress" is thought to contribute to the pathogenesis of a number of human diseases including those of the lung. Recent studies have also implicated ROS that are generated by specialized plasma membrane oxidases in normal physiological signaling by growth factors and cytokines. In this review, we examine the evidence for ligand-induced generation of ROS, its cellular sources, and the signaling pathways that are activated. Emerging concepts on the mechanisms of signal transduction by ROS that involve alterations in cellular redox state and oxidative modifications of proteins are also discussed.