ALBENDAZOLE AND INFECTIONS WITH ASCARIS-LUMBRICOIDES AND TRICHURIS-TRICHIURA IN CHILDREN IN BANGLADESH
ALBENDAZOLE AND INFECTIONS WITH ASCARIS-LUMBRICOIDES AND TRICHURIS-TRICHIURA IN CHILDREN IN BANGLADESH
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DOI：
10.1016/0035-9203(94)90525-8
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发表时间：
1994-01-01
影响因子：
2.2
通讯作者：
NAHAR, Q
中科院分区：
文献类型：
--
作者：
HALL, A;NAHAR, Q
用阿苯达唑600 mg或800 mg单次给药或400 mg/d，连用3 d或5 d，治疗245例鞭虫感染儿童，其中143例合并蛔虫感染。在治疗后10天内检查了三次粪便，并在近40天后再次检查，使用定量显微镜技术。阿苯达唑对A.但在10 d内，所有剂量均治愈了约92%的感染。与此相反，阿苯达唑最初似乎抑制T。毛，然后恢复。单次给药对T.鞭毛虫各<30%，阿苯达唑400 mg，连用3 d，治愈率为80%。这些结果的影响进行了简要讨论。
Two hundred and forty-five children infected with Trichuris trichiura, 143 of whom were also infected with Ascaris lumbricoides, were treated with albendazole as follows: single doses of either 600 mg or 800 mg, or daily doses of 400 mg for either 3 d or 5 d. Three stools were examined over a period of 10 d after treatment and again after nearly 40 d, using a quantitative microscopical technique. Albendazole appeared to act slowly against A. lumbricoides but within 10 d all dosages had cured about 92% of infections. In contrast, albendazole appeared initially to inhibit egg production by T. trichiura, which was then resumed. The single doses gave poor cure and egg reduction rates for T. trichiura of less than 30% each, and 400 mg of albendazole for 3 d was required to achieve a cure rate of 80%. The implications of these results are briefly discussed.