Daytime alertness, insomnia, and benzodiazepines.
Daytime alertness, insomnia, and benzodiazepines.
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白天警觉性、失眠和苯二氮卓类药物。
DOI：
10.1093/sleep/5.suppl_1.s28
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发表时间：
1982
期刊：
影响因子：
5.6
通讯作者：
Carskadon,M
中科院分区：
文献类型：
--
作者：
Dement,W;Seidel,W;Carskadon,M
为了将白天的警觉性作为失眠评估及其治疗的基本部分，必须客观和定量地测量嗜睡和警觉性的水平。随着多次睡眠潜伏期测试（Multiple Sleep Latency Test，MPEST）的发展，这一方法学上的挑战已经被克服。本文介绍了这种方法，文件的评价，并提出了其应用的例子，苯二氮卓类催眠药的评价。数据表明，MPEG4提供了最可靠和最敏感的方法来评估与各种各样的实验操作相关的日间警觉性的变化。MPEG4似乎对总睡眠时间的微小变化很敏感，动机和实践效果似乎是最小的，并且该措施可以应用于患者和非患者。它的结论是，测量白天的警觉性/嗜睡的尺寸应该是急性和慢性失眠患者的诊断和治疗的一个重要组成部分。(24参考）（PsycINFO数据库记录（c）2017阿帕，保留所有权利）
To incorporate daytime alertness as a fundamental part of the evaluation of insomnia and its treatment, levels of sleepiness and alertness must be measured objectively and quantitatively. This methodological challenge has been overcome with the development of the Multiple Sleep Latency Test (MSLT). The present papar describes this approach, documents its evaluation, and presents examples of its application to the evaluation of benzodiazepine hypnotics. Data indicate that the MSLT offers the most reliable and sensitive approach to the assessment of changes in daytime alertness associated with a wide variety of experimental manipulations. The MSLT appears to be sensitive to very small changes in total sleep time, motivational and practice effects appear to be minimal, and the measure can be applied to both patients and nonpatients. It is concluded that measurement of the dimension of daytime alertness/sleepiness should be a major part of the diagnosis and treatment of patients with acute and chronic insomnia.(24 ref)(PsycINFO Database Record (c) 2017 APA, all rights reserved)