Regional cerebral metabolic asymmetries replicated in an independent group of patients with panic disorder
Regional cerebral metabolic asymmetries replicated in an independent group of patients with panic disorder
复制标题
DOI：
10.1016/s0006-3223(98)00026-2
复制
发表时间：
1998-11-15
影响因子：
10.6
通讯作者：
Cohen, RM
中科院分区：
文献类型：
--
作者：
Nordahl, TE;Stein, MB;Cohen, RM
背景资料：局部脑葡萄糖代谢率（rCMRglc）的异常左/右（L/R）半球比率（海马和下前额叶皮层）已注意到在未经药物治疗的惊恐障碍患者，方法：使用正电子发射断层扫描对一组独立的接受丙咪嗪治疗的惊恐障碍患者进行了研究，测试了正常化与异常rCMRglc比率持续存在的证据，丙咪嗪治疗的和以前报道的未用药的惊恐障碍患者之间的眶额rCMRglc值的差异进行了测试，检查的证据表明，差异将类似于用氯丙咪嗪治疗的强迫症（OCD）患者。我们发现在丙咪嗪治疗的惊恐障碍患者中同样异常低的UR海马和后下前额rCMRglc比率，此外，我们发现在丙咪嗪治疗的惊恐障碍患者中，与未用药的惊恐障碍患者相比，后眶额rCMRglc降低。这些异常的不对称性在未用药的惊恐障碍患者中发现，现在，在丙咪嗪治疗的惊恐障碍患者中可能反映了一种特质异常，丙咪嗪组和对照组的眶额rCMRglc差异治疗和未用药患者的变化与氯丙咪嗪治疗的强迫症患者的变化相似，可能反映了丙咪嗪治疗惊恐障碍患者，（C）1998年生物精神病学学会。
Background: Abnormal left/right (L/R) hemispheric ratios of regional cerebral glucose metabolic rates (rCMRglc) (hippocampus and inferior prefrontal cortex) have been noted in unmedicated panic disorder patients,Methods: An independent group of panic disorder patients placed on imipramine was studied with positron-emission tomography, testing for evidence of normalization versus persistence of the abnormal rCMRglc ratios, Differences in orbital frontal rCMRglc values between the imipramine-treated and the previously reported unmedicated panic disorder patients were tested examining for evidence that the differences would resemble those noted in obsessive-compulsive disorder (OCD) patients treated with clomipramine.Results: We found the same abnormally low UR hippocampal and posterior inferior prefrontal rCMRglc ratios in the imipramine-treated panic disorder patients, In addition, we found posterior orbital frontal rCMRglc decreases in the imipramine-treated panic disorder patients compared with the unmedicated panic disorder patients,Conclusions: These abnormal asymmetries found in unmedicated panic disorder patients and now, in imipramine-treated panic disorder patients may reflect a trait abnormality, The orbital frontal rCMRglc differences between the imipramine-treated and unmedicated patients are similar to changes noted in OCD patients treated with clomipramine and may reflect direct or indirect effects of imipramine treatment in panic disorder patients, (C) 1998 Society of Biological Psychiatry.