Masanori Kasahara: Long-standing Immunogenetics co-editor steps down.
Masanori Kasahara: Long-standing Immunogenetics co-editor steps down.
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Masanori Kasahara：长期担任《免疫遗传学》联合编辑的辞职。
DOI：
10.1007/s00251-022-01265-6
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发表时间：
2022
期刊：
影响因子：
3.2
通讯作者：
Flajnik,MartinF
中科院分区：
文献类型：
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作者：
Flajnik,MartinF
在担任《免疫遗传学》联合编辑25年后，Kasahara Masanori辞职了。罗纳德·邦特罗普和我会非常想念他。他的智慧、谦逊、低调的幽默，以及最重要的，他的能力，使他成为科学家中的科学家，或者像我们美国人所说的“百万里挑一”。Masanori于1980年在北海道大学获得医学博士学位，并于1984年获得博士学位，在那里他研究了MHC II类分子的血清学。他在图宾根的马克斯·普朗克生物学研究所（Max Planck Institute for Biology）与简·克莱因（Jan Klein）一起做博士后，研究小鼠17号染色体的遗传学和非人类灵长类动物的MHC，在那里他和其他人研究了MHC等位基因的跨物种进化。Masanori的独立工作首先涉及在小鼠17号染色体上编码的睾丸特异性基因tpx1，后来是tpx2。1986年，他搬到了迈阿密大学，在那里，简·克莱因（Jan Klein）在美国建立了第二个实验室。Masanori在迈阿密的“休赛期”经营这个实验室，并开始在那里成为一个独立的职位。就个人而言，1987年我从巴塞尔免疫学研究所（Basel Institute for Immunology）搬到迈阿密大学（University of Miami），从那时起，我和Masanori就开始合作。当他成为一名独立研究者时，Masanori将他的研究从非人类灵长类动物的MHC扩展到免疫系统的一般进化。Masanori的耐心远远超过了Job，他成功地指导了我分子生物学技术，我们一起克隆了许多两栖动物和鲨鱼的第一批MHC基因。直到今天，我们还在基础科学项目和几篇评论文章上继续合作（一起写这些文章很有趣）。不幸的是，对我和迈阿密大学来说，1992年，正盛回到北海道担任副教授，在接下来的28年里，他迅速晋升为教授、院长，最后成为迈阿密大学的代理校长。他在1996年取得了最高的科学成就，当时他在小鼠和人类基因组中发现了四个MHC旁系区域，这与大野在1970年提出的两轮基因组复制一致。MHC旁系区域的发现几乎与另一个实验室的工作同时进行，该实验室发现了有颌脊椎动物中hox基因的四个旁系区域，而无脊椎动物中只有一个这样的区域。由于这些发现，正如预期的那样，人们可以为在颌口动物中发现的任何共系基因群找到类似的区域。目前，通过比较基因组分析，我们接近揭开MHC（和其他适应性免疫基因）的起源。1996年，Masanori的开创性工作使这一进展成为可能，该工作为理解大型遗传区域的进化提供了框架。Masanori还在胸腺特异性蛋白酶体β5t （NKG2D识别的非经典I类分子）和Agnathan可变淋巴细胞受体方面做了开创性的工作。他的论文写得无与伦比，文笔清晰，没有一个字不合时宜。有一天，我在他的桌子上看到一篇对他一篇论文的评论，上面写着：“我想我从来没有读过另一篇写得如此精确的论文。”这的确是很高的赞誉，但对于那些认识并与Masanori共事的人来说，这并不令人惊讶。他对由他的导师简·克莱因创立的免疫遗传学的贡献将永远不会被遗忘。
After 25 years as co-editor of Immunogenetics, Masanori Kasahara has stepped down. Ronald Bontrop and I will miss him enormously. His intelligence, humility, understated humor, and, most of all, his competence combine to define Masanori as a scientist’s scientist, or as we say in the USA “one in a million.” Masanori earned his MD in 1980 and his PhD in 1984 at the University of Hokkaido, where he examined the serology of MHC class II molecules. He did his postdoc at the Max Planck Institute for Biology in Tubingen with Jan Klein, examining the genetics of mouse chromosome 17 and the MHC of non-human primates, where he and others studied trans-species evolution of MHC alleles. Masanori’s independent work first involved a testes-specific gene encoded on mouse chromosome 17, tpx1, and later tpx2. He moved to the University of Miami in 1986, where Jan Klein had set up a second lab in the United States. Masanori ran this lab during the “off season” in Miami, and began his rise to an independent position there. On a personal level, Masanori and I have collaborated since our early days at the University of Miami, when I moved there from the Basel Institute for Immunology in 1987. When he became an independent investigator, Masanori expanded his research from non-human primate MHC to general evolution of the immune system. With patience far exceeding that of Job, Masanori succeeded in mentoring me in molecular biology techniques, and together we cloned many of the first MHC genes in amphibians and sharks. We have continued to collaborate to this day on basic-science projects and on several review articles (which have been a lot of fun to write together). Unfortunately for me, and for the University of Miami, Masanori returned to Hokkaido in 1992 as an Associate Professor, rapidly rising through the ranks over the next 28 years to become Professor, Dean, and finally Acting President of the university. His crowning scientific achievement was attained in 1996, when he discovered four MHC paralogous regions in the mouse and human genomes, consistent with a proposed two rounds of genome duplication proposed by Ohno in 1970. This discovery of the MHC paralogous regions was nearly simultaneous with work done in another lab uncovering four paralogous regions of hox genes in jawed vertebrates and only one such region in the invertebrates. Since those discoveries, as expected, one can find paralogous regions for any syntenic group of genes found in the Gnathostomes. Currently, we are close to uncovering the origins of the MHC (and other adaptive immune genes) through comparative genomic analyses. This progress was made possible by Masanori’s groundbreaking work in 1996, which provided the framework for understanding the evolution of large genetic regions. Masanori has also done pioneering work on the thymicspecific proteasome β5t, nonclassical class I molecules recognized by NKG2D, and on the Agnathan Variable Lymphocyte Receptors. His papers are written in an incomparable, lucid style with nary a word out of place. One day I saw on his desk a review of one of his papers, which said,“I don’t think I’ve ever read another paper written with such precision.” High praise indeed, but not a surprising accolade to those who have known and worked with Masanori. His dedication to Immunogenetics, which was founded by his mentor Jan Klein, will never be forgotten.