Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function
Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function
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DOI：
10.1172/jci11620
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发表时间：
2000-11-01
影响因子：
15.9
通讯作者：
Khachigian, LM
中科院分区：
文献类型：
--
作者：
Khachigian, LM
Egr-1依赖性损伤反应模型。血管细胞的损伤释放预先形成的内源性生长因子（如FGF-2），其通过促分裂原活化蛋白激酶（MAPK）以旁分泌方式激活Egr-1基因表达。Egr-1蛋白可以在某些启动子中取代重叠结合位点的Sp1，并增加其产物有助于新生内膜形成的病理生理相关基因的表达。R，受体。
Model of Egr-1–dependent response to injury. Injury to vascular cells releases preformed endogenous growth factors (such as FGF-2), which activate Egr-1 gene expression in a paracrine manner via mitogen-activated protein kinases (MAPKs). Egr-1 protein can, in certain promoters, displace Sp1 from overlapping binding sites and increase the expression of pathophysiologically relevant genes whose products contribute to neointima formation. R, receptor.