Development of visually evoked cortical activity monkeys studied longitudinally with in infant macaque fMRI
Development of visually evoked cortical activity monkeys studied longitudinally with in infant macaque fMRI
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DOI：
10.1016/j.mri.2005.12.025
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发表时间：
2006-05-01
影响因子：
2.5
通讯作者：
Kiorpes, Lynne
中科院分区：
文献类型：
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作者：
Kourtzi, Zoe;Augath, Mark;Kiorpes, Lynne
我们用BOLD PORI技术研究了两只103-561日龄幼猴在阿片类麻醉下视觉激活的纵向发育，并与在相同条件下研究的三只成年动物的结果进行了比较。在年龄最小和年龄最大的猴子身上，初级视觉皮质(VI)的视觉激活是强大和可靠的，这表明功能成像技术在婴儿和成年人身上得出了定性相似的结果。参与运动(MT/V5)和形式(V4)加工的纹外区的视觉激活在年轻动物中不明显，但在老年动物中变得更像成年人。纹外视皮层的这种可测量的大胆反应的延迟出现可能反映了这些区域视觉反应的延迟发展，尽管在这个阶段不能排除麻醉的影响或脑血管反应机制的改变是原因。在幼猴身上展示的视觉诱发的大胆反应表明，大胆的fMRI技术可以有效地用于解决大脑发育的功能问题。(C)2006 Elsevier Inc.保留所有权利。
We studied the development of visual activation longitudinally in two infant monkeys aged 103-561 days using the BOLD PORI technique under opiate anesthesia and compared the results with those obtained in three adult animals studied under identical conditions. Visual activation in primary visual cortex, V I, was strong and reliable in monkeys of the youngest and oldest ages, showing that functional imaging techniques give qualitatively similar results in infants and adults. Visual activation in extrastriate areas involved in processing motion (MT/V5) and form (V4) was not evident in the younger animals, but became more adult-like in the older animals. This delayed onset of measurable BOLD responses in extrastriate visual cortex may reflect delayed development of visual responses in these areas, although at this stage it is not possible to rule out either effects of anesthesia or of changes in cerebral vascular response mechanisms as the cause. The demonstration of visually evoked BOLD responses in young monkeys shows that the BOLD fMRI technique can usefully be employed to address functional questions of brain development. (c) 2006 Elsevier Inc. All rights reserved.