Analysis of the concentration-respiratory response among asthmatics following controlled short-term exposures to sulfur dioxide
Analysis of the concentration-respiratory response among asthmatics following controlled short-term exposures to sulfur dioxide
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DOI：
10.3109/08958378.2010.535220
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发表时间：
2010-12-01
影响因子：
2.1
通讯作者：
Linn, William S.
中科院分区：
文献类型：
--
作者：
Johns, Douglas O.;Svendsgaard, David;Linn, William S.
二氧化硫(SO2)引起呼吸道疾病的一些最令人信服的证据来自于大量研究，这些研究涉及哮喘志愿者群体中受控的短期暴露。这些研究在最近完成的关于二氧化硫的主要国家环境空气质量标准的审查中被广泛引用。尽管这些调查清楚地表明，接触二氧化硫可能会导致支气管收缩显著增加，但这种呼吸反应发生的浓度范围尚不确定。这项研究的目的是利用个体受试者的肺功能反应数据更好地描述二氧化硫和支气管收缩指标之间的浓度-反应关系。在回顾哮喘患者在5-10分钟的提升通风期间暴露于二氧化硫的研究中，我们观察到明确和一致的证据表明，随着暴露浓度在0.2至1.0ppm之间增加，对二氧化硫的支气管收缩反应增强。在随后对个别受试者数据的分析中，研究发现，在相对较高的暴露浓度下经历二氧化硫引起的呼吸影响的哮喘患者，在暴露于较低浓度的二氧化硫后也比无反应者更有可能经历类似的影响(
Some of the most compelling evidence of sulfur dioxide (SO2)-induced respiratory morbidity is derived from a large body of studies involving controlled short-term exposures among groups of asthmatic volunteers. These studies were extensively cited in the recently completed review of the primary National Ambient Air Quality Standards for SO2. Although it is clear from these investigations that exposure to SO2 may result in a significant increase in bronchoconstriction, there is uncertainty regarding the range of concentrations over which this respiratory response occurs. The objective of this study was to better characterize the concentration-response relationship between SO2 and measures of bronchoconstriction using individual subject lung function response data. In reviewing studies of asthmatics exposed to SO2 during 5- to 10-min periods of elevated ventilation, we observed clear and consistent evidence of an increase in the bronchoconstrictive response to SO2 with increasing exposure concentrations between 0.2 and 1.0 ppm. In a subsequent analysis of individual subject data, it was found that those asthmatics experiencing SO2-induced respiratory effects at relatively high exposure concentrations are also more likely than nonresponders to experience similar effects after exposure to lower SO2 concentrations (