Cohort study of cancer risk among male and female shift workers
Cohort study of cancer risk among male and female shift workers
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DOI：
10.5271/sjweh.1150
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发表时间：
2007-10-01
影响因子：
6.3
通讯作者：
Feychting, Maria
中科院分区：
文献类型：
--
作者：
Schwartzbaum, Judith;Ahlbom, Anders;Feychting, Maria
褪黑素是一种抑制实验性癌症的激素，夜间暴露在光线下会抑制褪黑素，因此夜班工作者患癌症的风险可能会增加。先前对轮班工人的研究发现，女性患乳腺癌的风险增加，并表明女性患结肠癌和前列腺癌的风险可能增加。目前的研究是为了看看这些先前的发现是否可以证实，以及轮班工人在其他地方患癌症的风险是否更高。方法对1960 ~ 1970年在职职工进行男2 102 126人、女1 148 661人的调查。研究人员根据轮班工人的比例对他们的工作进行分类，从1971年到1989年，或者直到他们被诊断出患有癌症或死亡。标准化发病率（SIR）用于比较轮班工人与非轮班工人的调整后癌症发病率。结果男性轮班工人的癌症发病率没有升高[所有站点合并：轮班工人中N=6524例，SIR 1.02, 95%可信区间（95% CI） 1.00-1.05；前列腺：N=1319例，SIR 1.04, 95% CI 0.99-1.10]或女性轮班工人（所有部位合并：N=268例，SIR 1.00, 95% CI 0.89-1.13；乳房：N=70例，SIR 0.94, 95% CI 0.74-1.18）。结论：没有证据表明倒班工作与乳腺癌或前列腺癌之间存在关联，也没有证据表明倒班工作与倒班工人罹患的所有癌症相关。
Objectives Melatonin, a hormone that inhibits experimentally induced cancers, is suppressed by nighttime exposure to light so that nighttime shift workers may be at an increased risk of cancer. Previous studies of shift workers found an increased risk of breast cancer among women and suggested a possible increased risk of colon cancer among women and prostate cancer. The present study was conducted to see whether these previous findings could be confirmed and whether shift workers are at elevated risk for cancer at additional sites.Methods Altogether 2 102 126 male and 1 148 661 female workers were identified who worked in both 1960 and 1970. Their jobs were classified according to the percentage of shift workers, and they were followed from 1971 through 1989 or until they were diagnosed with cancer or died. Standardized incidence ratios (SIR) were used to compare the adjusted cancer incidence rates for shift workers with those for nonshift workers.Results Cancer rates were not elevated for the male shift workers [all sites combined: N=6524 cases among shift workers, SIR 1.02, 95% confidence interval (95% CI) 1.00-1.05; prostate: N=1319, SIR 1.04, 95% CI 0.99-1.10] or for the female shift workers (all sites combined: N=268, SIR 1.00, 95% CI 0.89-1.13; breast: N=70 cases, SIR 0.94, 95% CI 0.74-1.18).Conclusions No evidence was found for an association between shift work and breast or prostate cancer, or all cancer sites combined among shift workers.