The Cells of Bone and Their Interactions
The Cells of Bone and Their Interactions
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DOI：
10.1007/164_2019_343
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发表时间：
2020-01-01
期刊：
影响因子：
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通讯作者：
Sims, Natalie A.
中科院分区：
文献类型：
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作者：
Ansari, Niloufar;Sims, Natalie A.
骨组织由富含胶原的基质组成，该基质含有非胶原有机化合物，并由矿物晶体强化。骨强度反映了骨的数量和结构，以及其质量。这些质量由骨表面上的成骨细胞（骨形成细胞）和破骨细胞（骨吸收细胞）以及嵌入骨基质内的骨细胞决定和维持。骨发育和生长也涉及软骨细胞（软骨细胞）。这些细胞不是孤立地起作用，而是以协调的方式起作用，包括每个谱系内、骨细胞之间以及这些细胞与骨微环境内的其他细胞类型之间的协调。这种通讯途径负责控制骨骼发育和重塑。
Bone tissue is comprised of a collagen-rich matrix containing non-collagenous organic compounds, strengthened by mineral crystals. Bone strength reflects the amount and structure of bone, as well as its quality. These qualities are determined and maintained by osteoblasts (bone-forming cells) and osteoclasts (bone-resorbing cells) on the surface of the bone and osteocytes embedded within the bone matrix. Bone development and growth also involves cartilage cells (chondrocytes). These cells do not act in isolation, but function in a coordinated manner, including co-ordination within each lineage, between the cells of bone, and between these cells and other cell types within the bone microenvironment. This communication pathways responsible for controlling bone development and remodeling.