Venous blood gas and metabolite response to low-intensity muscle contractions with external limb compression
Venous blood gas and metabolite response to low-intensity muscle contractions with external limb compression
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DOI：
10.1016/j.metabol.2010.01.016
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发表时间：
2010-10-01
影响因子：
9.8
通讯作者：
Nakajima, Toshiaki
中科院分区：
文献类型：
--
作者：
Yasuda, Tomohiro;Abe, Takashi;Nakajima, Toshiaki
研究低强度抗阻运动加肢体外压（100 [EC 1001]和160 [EC I 60] mm Hg）对肢体血流和静脉血气代谢反应的影响，并与高强度抗阻运动（无外压）进行比较。单侧屈肘肌收缩以20%（75次重复，4组，30秒休息间隔）和70%的1次重复最大值（1-RM; 3组，每组直至失败，3分钟休息间隔）进行。收缩前肱动脉血流（多普勒超声）减少与EC 100或EC 160（基线值的56%和39%，分别）相比，没有外部压缩（对照）。在20%1-RM时，用EC 160进行收缩后肱动脉血流量增加（190%），而用其他收缩剂则没有。在EC 100和EC 160期间，静脉氧分压（PvO 2）和静脉氧饱和度（SvO 2）的下降幅度大于对照组（平均值[SE]：PvO 2，分别为28 [3] vs 26 [2] vs 33 [2] mm Hg; SvO 2，分别为41% [5%] vs 34% [4%] vs 52% [5%]）。静脉pH（pH（v））、静脉二氧化碳分压（PvCO 2）和静脉乳酸浓度（[L-]（v））的变化在EC 160组大于EC 100和/或对照组（pH（v）7.19 [0.01] vs 7.25 [0.01] vs 7.27 [0.02]; PvCO 2，分别为72 [3] vs 64 [2] vs 60 [3] mm [L-]（v），5.4 [0.6] vs 3.7 [0.4] vs 3.0 [0.4] mmol/L）。70%的1-RM收缩导致pH（v）（7.14 [0.02]）、PvCO 2（91 [5] mm Hg）和[L-]（v）（7.0 [0.5] mmol/L）的变化大于EC 100和EC 160，但PvO 2（30 [4] mm Hg）和SvO 2（40% [3%]）相似。总之，pH（v），PvCO 2和[L-]（v）的变化，但不是在PvO 2和SvO 2，是敏感的相对变化，“内部”强度的低强度肌肉收缩引起的血流量减少（EC 160）或高强度肌肉收缩。考虑到pH（v）、PvCO 2和[L-]（v）的变化幅度，似乎合理的是，它们可能参与了通过III组和IV组传入刺激观察到的肌肉激活增加。(C)2010年爱思唯尔公司All rights reserved.
The effect of low-intensity resistance exercise with external limb compression (100 [EC 1001 and 160 [EC I 60] mm Hg) on limb blood flow and venous blood gas-metabolite response was investigated and compared with that of high-intensity resistance exercise (no external compression). Unilateral elbow flexion muscle contractions were performed at 20% (75 repetitions, 4 sets, 30-second rest intervals) and 70% of 1-repetition maximum (1-RM; 3 sets, each set was until failure, 3-minute rest intervals). Precontraction brachial arterial blood flow (Doppler ultrasound) was reduced with EC100 or EC160 (56% and 39% of baseline value, respectively) compared with no external compression (control). At 20% 1-RM, brachial arterial blood flow increased after contractions performed with EC160 (190%), but not with the others. Decreases in venous oxygen partial pressure (PvO2) and venous oxygen saturation (SvO2) were greater during EC100 and EC160 than control (mean [SE]: PvO2, 28 [3] vs 26 [2] vs 33 [2] mm Hg; SvO2, 41% [5%] vs 34% [4%] vs 52% [5%], respectively). Changes in venous pH (pH(v)), venous carbon dioxide partial pressure (PvCO2), and venous lactate concentration ([L-](v)) were greater with EC160 than EC100 and/or control (pH(v) 7.19 [0.01] vs 7.25 [0.01] vs 7.27 [0.02]; PvCO2, 72 [3] vs 64 [2] vs 60 [3] mm [L-](v), 5.4 [0.6] vs 3.7 [0.4] vs 3.0 [0.4] mmol/L, respectively). Seventy percent 1-RM contractions resulted in greater changes in pH(v) (7.14 [0.02]), PvCO2 (91 [5] mm Hg), and [L-](v) (7.0 [0.5] mmol/L) than EC100 and EC160, but PvO2 (30 [4] mm Hg) and SvO2 (40% [3%]) were similar. In conclusion, changes in pH(v), PvCO2, and [L-](v), but not in PvO2 and SvO2, are sensitive to changes in relative, "internal" intensity of low-intensity muscle contractions caused by reduced blood flow (EC160) or high-intensity muscle contractions. Given the magnitude of the changes in pH(v), PvCO2, and [L-](v), it appears plausible that they may be involved in stimulating the observed increase in muscle activation via group III and IV afferents. (C) 2010 Elsevier Inc. All rights reserved.