Mucosal administration of flagellin induces innate immunity in the mouse lung
Mucosal administration of flagellin induces innate immunity in the mouse lung
复制标题
DOI：
10.1128/iai.72.11.6676-6679.2004
复制
发表时间：
2004-11-01
影响因子：
3.1
通讯作者：
Mizel, SB
中科院分区：
文献类型：
--
作者：
Honko, AN;Mizel, SB
在几个品系的小鼠中，非手术气管内滴注1杯纯化的重组鞭毛蛋白，可在肺内刺激短暂的先天免疫反应，其特征是中性粒细胞的渗透，并迅速产生肿瘤坏死因子α、白细胞介素6、粒细胞集落刺激因子以及趋化因子角质形成细胞衍生的趋化因子MIP1α和MIP-2。
Nonsurgical intratracheal instillation of 1 mug of purified, recombinant flagellin in several strains of mice stimulated a transient innate immune response in the lung characterized by the infiltration of neutrophils and the rapid production of tumor necrosis factor alpha, interleukin 6, granulocyte colony-stimulating factor, and the chemokines keratinocyte-derived chemokine, MIP1alpha, and MIP-2.