Serum albumin levels in ischemic stroke and its subtypes: Correlation with clinical outcome
Serum albumin levels in ischemic stroke and its subtypes: Correlation with clinical outcome
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DOI：
10.1016/j.nut.2012.12.015
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发表时间：
2013-06-01
期刊：
影响因子：
4.4
通讯作者：
Munshi, Anjana
中科院分区：
文献类型：
--
作者：
Babu, Mallemoggala Sai;Kaul, Subhash;Munshi, Anjana
目的：以前的研究表明低血清白蛋白水平与缺血性卒中预后不良有关。动物实验也证实了血清白蛋白在局灶性缺血中的神经保护作用。然而，关于血清白蛋白水平与缺血性卒中亚型预后相关性的研究非常有限。本研究旨在探讨血清白蛋白水平与缺血性脑卒中及其亚型预后的关系。评估血清白蛋白水平，并在术后3个月进行随访以确定卒中结局。校正潜在混杂因素后，通过多元逻辑回归分析评估血清白蛋白水平与卒中结局之间的相关性。结果：低水平白蛋白与不良结局显著相关（改良兰金量表评分>3分）。调整后的比值比为1.972（95%可信区间，1.103-4.001; P < 0.001）。与白蛋白水平升高的患者相比，白蛋白水平低的患者卒中复发率和死亡率也较高。根据吐司（ORG 10172急性卒中治疗试验）分类的所有卒中亚型中，血清白蛋白水平的降低与不良结局显著相关。(C)2013 Elsevier Inc. All rights reserved.
Objective: Previous studies have associated low serum albumin levels with poor outcome in ischemic stroke. Animal studies also demonstrated neuroprotective effects of serum albumin in focal ischemia. However, there are very limited studies on the association of serum albumin levels with stroke outcome in ischemic stroke divided into subtypes. The present study was carried out to investigate the association of serum albumin levels with outcome in ischemic stroke and its subtypes.Methods: The study involved 560 patients. Serum albumin levels were estimated and follow-up interviews were conducted at 3 mo postevent to determine stroke outcome. The association between serum albumin levels and stroke outcome was evaluated by multiple logistic regression analysis after adjustment for potential confounders.Results: Low levels of albumin associated significantly with poor outcome (score of >3 on the modified Rankin Scale). The adjusted odds ratio was 1.972 (95% confidence interval, 1.103-4.001; P < 0.001). The recurrence of stroke and death rate also was high in patients with low levels of albumin compared with patients with elevated levels of albumin. The reduced level of serum albumin associated significantly with poor outcome in all the stroke subtypes classified according to TOAST (Trial of ORG 10172 in Acute Stroke Treatment).Conclusions: Relatively high serum albumin levels in acute stroke decrease poor outcome. (C) 2013 Elsevier Inc. All rights reserved.