HLA antigens in juvenile arthritis. Pauciarticular and polyarticular juvenile arthritis are immunogenetically distinct.
HLA antigens in juvenile arthritis. Pauciarticular and polyarticular juvenile arthritis are immunogenetically distinct.
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幼年关节炎中的 HLA 抗原。
DOI：
10.1002/art.1780331205
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发表时间：
1990
影响因子：
--
通讯作者：
Stastny,P
中科院分区：
文献类型：
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作者：
Fernandez-Viña,MA;Fink,CW;Stastny,P
利用DNA技术，我们研究了HLA-DR，DQ和DP等位基因在幼年关节炎（JA）易感性中的作用。我们研究了两组具有不同疾病预后和病程的JA患者。少关节型通常是良性的，而多关节型疾病经常导致关节破坏和残疾。HLA-DRw 13-Dw 18和DQw 6-Dw 18的患者优先发生持续性少关节疾病，但这些抗原并不赋予疾病转化为多关节形式的患者易感性。HLA-DPw 2.1是少关节型JA的另一易感因素。在多关节型JA中，HLA-DPw 3是主要的易感因素，相对危险度为10.3（P< 0.0001）。此外，我们还发现在少关节和多关节疾病患者中，DRw8.1和DQw 4明显增高，而HLA-DR 4明显降低。这些结果表明，除了一些共同的因素，不同的HLA II类等位基因是重要的少关节或多关节JA。我们的结论是，分型与寡核苷酸探针可能是有用的，在一些儿童关节炎的预测结果。
Using DNA techniques, we investigated the role of HLA—DR, DQ, and DP alleles in susceptibility to juvenile arthritis (JA). We studied 2 groups of patients with JA having a different disease prognosis and course. The pauciarticular form is usually benign, while the polyarticular disease frequently leads to joint destruction and disability. Persistent pauciarticular disease developed preferentially in patients having HLA—DRw13‐Dw18 and DQw6‐Dw18, but these antigens did not confer susceptibility in patients whose disease converted to the polyarticular form. HLA—DPw2.1 was an additional susceptibility factor for patients with JA of pauciarticular onset. In the polyarticular form of JA, HLA—DPw3 was the major factor for susceptibility, giving a relative risk of 10.3 (P< 0.0001). In addition, we found that DRw8.1 and DQw4 were increased, and HLA—DR4 was markedly decreased, in patients with pauciarticular and polyarticular disease. These results indicate that in addition to some shared factors, distinct HLA class II alleles are important in pauciarticular or polyarticular JA. We conclude that typing with oligonucleotide probes may be useful in predicting the outcome in some children with arthritis.