Effect of diethyl maleate on the biliary excretion rate of infused sulfobromophthalein-glutathione.
Effect of diethyl maleate on the biliary excretion rate of infused sulfobromophthalein-glutathione.
复制标题
马来酸二乙酯对输注磺基溴酞谷胱甘肽胆汁排泄率的影响。
DOI：
10.1016/0006-2952(82)90716-x
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发表时间：
1982
影响因子：
5.8
通讯作者：
Backof,B
中科院分区：
文献类型：
--
作者：
Combes,B;Backof,B
马来酸二乙酯（DEM）腹腔内给予大鼠的剂量（4.3毫摩尔/公斤），已知显着降低肝脏谷胱甘肽水平。DEM诱导胆汁分泌先前显示是由于DEM结合物（DEM-谷胱甘肽和随后的代谢产物）分泌到胆汁中的渗透活性。与胆汁分泌相一致，输注磺溴酞谷胱甘肽结合物（BSP-GSH）的胆汁排泄Tm显著降低。这些数据被解释为表明DEM-GSH缀合物与BSP-GSH缀合物竞争小管载体机制。
Diethyl maleate (DEM) was given intraperitoneally to rats in a dose (4.3 mmoles/kg) known to markedly decrease glutathione levels in liver. DEM induced a choleresis previously shown to be due to the osmotic activity of DEM conjugates (DEM-glutathione and subsequent metabolic products) excreted into bile. Coincident with the choleresis, the biliary excretory Tm for the infused glutathione conjugate of sulfobromophthalein (BSP-GSH) was depressed significantly. The data are interpreted as indicating that DEM-GSH conjugates compete with BSP-GSH conjugates for a canalicular carrier mechanism.