Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems.
Advancing Cancer Therapy with Copper/Disulfiram Nanomedicines and Drug Delivery Systems.
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DOI：
10.3390/pharmaceutics15061567
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发表时间：
2023-05-23
期刊：
影响因子：
5.4
通讯作者：
Chen P
中科院分区：
文献类型：
--
作者：
Kang X;Jadhav S;Annaji M;Huang CH;Amin R;Shen J;Ashby CR Jr;Tiwari AK;Babu RJ;Chen P
双硫仑 (DSF) 是一种硫代氨基甲酸盐药物，已被批准用于治疗酒精中毒 60 多年。临床前研究表明，DSF具有抗癌功效，并且补充铜（CuII）可显着增强DSF的功效。然而，临床试验的结果并未产生有希望的结果。阐明 DSF/Cu (II) 的抗癌机制将有助于重新利用 DSF 作为某些类型癌症的新治疗方法。 DSF的抗癌机制主要是由于其产生活性氧、抑制乙醛脱氢酶（ALDH）活性抑制、降低转录蛋白水平。 DSF 还对癌细胞增殖、癌症干细胞 (CSC) 自我更新、血管生成、耐药性和抑制癌细胞转移具有抑制作用。本综述还讨论了目前 DSF 单独的二乙基二硫代氨基甲酸酯 (DDC)、Cu (II) 和 DSF/Cu (II) 以及有效成分二乙基二硫代氨基甲酸酯-铜络合物 (CuET) 的给药策略。
Disulfiram (DSF) is a thiocarbamate based drug that has been approved for treating alcoholism for over 60 years. Preclinical studies have shown that DSF has anticancer efficacy, and its supplementation with copper (CuII) significantly potentiates the efficacy of DSF. However, the results of clinical trials have not yielded promising results. The elucidation of the anticancer mechanisms of DSF/Cu (II) will be beneficial in repurposing DSF as a new treatment for certain types of cancer. DSF’s anticancer mechanism is primarily due to its generating reactive oxygen species, inhibiting aldehyde dehydrogenase (ALDH) activity inhibition, and decreasing the levels of transcriptional proteins. DSF also shows inhibitory effects in cancer cell proliferation, the self-renewal of cancer stem cells (CSCs), angiogenesis, drug resistance, and suppresses cancer cell metastasis. This review also discusses current drug delivery strategies for DSF alone diethyldithocarbamate (DDC), Cu (II) and DSF/Cu (II), and the efficacious component Diethyldithiocarbamate–copper complex (CuET).
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影响因子：
--
作者：
Ayala A;Muñoz MF;Argüelles S
通讯作者：
Argüelles S
影响因子：
5.8
作者：
Banerjee, Parikshit;Geng, Tianjiao;Wang, Bo
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DOI：
10.1152/ajpcell.2001.280.3.c659
发表时间：
2001-03-01
影响因子：
5.5
作者：
Brar, SS;Kennedy, TP;Hoidal, JR
通讯作者：
Hoidal, JR
影响因子：
3.1
作者：
Chen, D;Peng, FY;Dou, QP
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Dou, QP
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Cheriyan VT;Wang Y;Muthu M;Jamal S;Chen D;Yang H;Polin LA;Tarca AL;Pass HI;Dou QP;Sharma S;Wali A;Rishi AK
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Rishi AK