An Evaluation of Mass Screening Using Fecal Occult Blood Test for Colorectal Cancer in Japan: A Case‐Control Study
An Evaluation of Mass Screening Using Fecal Occult Blood Test for Colorectal Cancer in Japan: A Case‐Control Study
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日本使用粪便潜血试验进行结直肠癌大规模筛查的评估：病例对照研究
DOI：
10.1111/j.1349-7006.1993.tb02809.x
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发表时间：
1993
期刊：
影响因子：
--
通讯作者：
T. Toyota
中科院分区：
文献类型：
--
作者：
N. Hiwatashi;Tomizo Morimoto;A. Fukao;Hirofusa Sato;N. Sugahara;S. Hisamichi;T. Toyota
到目前为止，还没有确凿的证据表明，使用粪便潜血试验(FOBT)对结直肠癌进行大规模筛查可以降低这种癌症的死亡率。因此，我们通过日本宫城县的病例对照研究评估了筛查的效果。研究对象包括28名在被诊断为结直肠癌之日之前有机会参加大规模筛查的结直肠癌死亡患者，每个病例对象随机选择3名对照，这些对照是从病例对象死亡之日活着的居民中随机选择的，并使用住宅档案按性别、年龄(3年内)和居住地区进行匹配。对于每一组，即一个病例受试者和3个对照，检查了在病例被诊断为结直肠癌之前的筛查历史。在确诊日期前3年内至少参加过一次筛查的病例受试者和对照组均被归类为“筛查”。病例组28例，男12例，女16例，平均年龄60.8岁。根据Mantel-Haenszel方法，筛查者与未筛查者死于结直肠癌的优势比为0.24(95%可信区间=0.08-0.76)。目前的研究表明，使用FOBTS对结直肠癌进行大规模筛查在流行病学上显著降低了这种癌症的死亡率。
There is as yet no firm evidence showing that mass screening for colorectal cancer using fecal occult blood tests (FOBTs) reduces the mortality from this cancer. Therefore we evaluated the effectiveness of the screening by a case‐control study in Miyagi Prefecture, Japan. The study included as case subjects 28 individuals who had died from colorectal cancer and had had an opportunity to participate in the mass screening before the date of diagnosis as colorectal cancer, and 3 controls for each case subject randomly selected from residents who were alive on the date of death of case subjects and matched by sex, age (within 3 years) and living area using residential files. For each set, i.e., a case subject and 3 controls, screening histories before the date of the diagnosis of the case as colorectal cancer were examined. Both the case subjects and the controls who had participated in the screening at least once within 3 years before the date of diagnosis of the case were classified as “screened.” The 28 case subjects consisted of 12 males and 16 females (average age: 60.8 years). The odds ratio of death from colorectal cancer for the screened versus the non‐screened persons was 0.24 (95% confidence interval = 0.08–0.76) by the Mantel‐Haenszel method. The present study suggests that mass screening using FOBTs for colorectal cancer significantly reduces the mortality from this cancer epidemiologically.
影响因子：
158.5
作者：
MANDEL, JS;BOND, JH;EDERER, F
通讯作者：
EDERER, F