CHLORTHALIDONE REDUCES CALCIUM-OXALATE CALCULOUS RECURRENCE BUT MAGNESIUM-HYDROXIDE DOES NOT
CHLORTHALIDONE REDUCES CALCIUM-OXALATE CALCULOUS RECURRENCE BUT MAGNESIUM-HYDROXIDE DOES NOT
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DOI：
10.1016/s0022-5347(17)42599-7
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发表时间：
1988-04-01
影响因子：
6.6
通讯作者：
DOLMAN, LI
中科院分区：
文献类型：
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作者：
ETTINGER, B;CITRON, JT;DOLMAN, LI
我们检测了氯替利酮或氢氧化镁预防草酸钙肾结石复发的有效性。在双盲随机分配设计中，每日剂量为25或50毫克。氯苯醚酮，650或1,300毫克。服用氢氧化镁或相同的安慰剂。所有组均显示，与治疗前相比，结石事件显著减少。在试验期间，安慰剂组出现的结石比预期的少56.1%(p<0.01)，而服用低剂量和高剂量氢氧化镁的组显示结石分别减少73.9%和62.3%(p分别低于0.001和<0.01)。氯苯吡酮治疗的结果比预测率下降了90.1%，两种剂量产生了相似的结果。当两种治疗方法进行比较时，氯替利酮显着优于安慰剂或氢氧化镁(p<0.01)。在给予安慰剂或无效治疗时，结石事件的大量减少强调了当使用历史对照时发生的积极治疗偏向，它们表明了适当试验设计的必要性。
We examined the effectiveness of chlorthalidone or magnesium hydroxide in the prevention of recurrent calcium oxalate kidney calculi. In a double-blind random allocation design daily dosages of 25 or 50 mg. chlorthalidone, 650 or 1,300 mg. magnesium hydroxide, or an identical placebo were adminsistered. All groups showecd significantly decreased calculous events compared to the pretreatment rates. During the trial 56.1 per cent few calculi than predicted developed in the placebo group (p less than 0.01), whereas the groups receiving low and high dosage magnesium hydroxide showed 73.9 and 62.3 per cent fewer calculi, respectively (p less than 0.001 and less than 0.01, respectively). Chlorthalidone treatment resulted in a 90.1 per cent decrease from predicted rates and both dosages yielded similar results. When the treatments were compared chlorthalidone was significantly better than the placebo or magnesium hydroxide (p less than 0.01). Thelarge decreases in calculous events seen when placebo or ineffective therapy was given underscore the positive treatment bias that occurs when historical controls are used and they demonstrate the need for proper experimental design.