Facilitating Ir-Catalyzed C-H Alkynylation with Electrochemistry: Anodic Oxidation-Induced Reductive Elimination.
Facilitating Ir-Catalyzed C-H Alkynylation with Electrochemistry: Anodic Oxidation-Induced Reductive Elimination.
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DOI：
10.1021/acscatal.0c03207
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发表时间：
2020-09
期刊：
影响因子：
12.9
通讯作者：
X. Ye;Chen-Hsiang Wang;Shuyao Zhang;Jing-De Wei;Chuan Shan;L. Wojtas;Yan Xie;Xiaodong Shi
中科院分区：
文献类型：
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作者：
X. Ye;Chen-Hsiang Wang;Shuyao Zhang;Jing-De Wei;Chuan Shan;L. Wojtas;Yan Xie;Xiaodong Shi
本文报道了一种电化学方法促进末端炔与C-H的直接炔基化反应。这项工作采用阳极氧化的Ir（III）中间体（其特征在于X射线晶体学），以促进还原消除，得到所需的耦合产品在良好的产率（高达95%），而无需添加任何其他外部氧化剂。这种转化适用于各种定向基团，H2作为唯一的副产物，这保证了在温和条件下的高原子经济性和实用的氧化C-C键形成。
An electrochemical approach in promoting directed C-H alkynylation with terminal alkyne via iridium catalysis is reported. This work employed anodic oxidation of Ir(III) intermediate (characterized by X-ray crystallography) to promote reductive elimination, giving the desired coupling products in good yields (up to 95%) without the addition of any other external oxidants. This transformation is suitable for various directing groups with H2 as the only by-product, which warrants a high atom economy and practical oxidative C-C bond formation under mild conditions.