Do personality traits moderate the manifestation of type 2 diabetes genetic risk?
Do personality traits moderate the manifestation of type 2 diabetes genetic risk?
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DOI：
10.1016/j.jpsychores.2015.07.003
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发表时间：
2015-10
影响因子：
4.7
通讯作者：
Deary IJ
中科院分区：
文献类型：
--
作者：
Čukić I;Mõttus R;Luciano M;Starr JM;Weiss A;Deary IJ
Objective.测试人格特质是否会降低2型糖尿病（T2 D）的遗传风险。方法.使用一个大型社区居住样本（n = 837，法师= 69.59 ± 0.85岁，49%男性），我们拟合了一系列线性回归模型，预测糖化血红蛋白（HbA 1c）从T2 D多基因风险-聚集大量单核苷酸多态性（SNP）的小个体效应-和五个人格特质。我们测试了人格特质的主要影响及其与T2 D多基因风险评分的相互作用，控制了年龄和性别。最后一组中的模型根据认知能力、最高学历和职业类别进行了调整。结果较低水平的开放性与HbA 1c水平升高相关（β =-0.014，p = 0.032）。T2 D多基因风险评分与宜人性之间存在显著的相互作用：较低的宜人性与T2 D多基因风险和HbA 1c之间的较强关联相关（β =-0.08，p = .021）。在调整认知能力的模型中，开放性的主效应不显著（β =-0.08，p = 0.057）。在控制认知能力和社会经济状况指标后，宜人性和T2 D多基因风险之间的相互作用仍然存在，并且易性和多基因风险评分之间的相互作用也很显著：较低的易性与T2 D多基因风险和HbA 1c水平之间的较强关联相关（β = 0.09，p = 0.04）。结论.个性可能与糖尿病的标志物有关，并可能调节其遗传风险的表达。我们测试了性格是否会调节2型糖尿病（T2 D）的遗传风险。在调整认知能力之前，较低的O与较高的HbA 1c相关。在低A和低C人群中，T2 D多基因风险与HbA 1c的相关性更强。调整社会经济地位并没有改变这种关系。性格可能会影响T2 D的遗传倾向。
Objective. To test whether personality traits moderate type 2 diabetes (T2D) genetic risk. Methods. Using a large community-dwelling sample (n = 837, Mage = 69.59 ± 0.85 years, 49% males) we fitted a series of linear regression models predicting glycated haemoglobin (HbA1c) from T2D polygenic risk — aggregation of small individual effects of a large number of single nucleotide polymorphisms (SNPs) — and five personality traits. We tested the main effects of personality traits and their interactions with T2D polygenic risk score, controlling for age and sex. The models in the final set were adjusted for cognitive ability, highest educational qualification, and occupational class. Results. Lower levels of openness were associated with heightened levels of HbA1c (β = − 0.014, p = .032). There was a significant interaction between T2D polygenic risk score and agreeableness: lower agreeableness was related to a stronger association between T2D polygenic risk and HbA1c (β = − 0.08, p = .021). In the model adjusted for cognitive ability, the main effect of openness was not significant (β = − 0.08, p = .057). The interaction between agreeableness and T2D polygenic risk was still present after controlling for cognitive ability and socioeconomic status indicators, and the interaction between conscientiousness and polygenic risk score was also significant: lower conscientiousness was associated with a stronger association between T2D polygenic risk and HbA1c levels (β = 0.09, p = .04). Conclusions. Personality may be associated with markers of diabetes, and may moderate the expression of its genetic risk. We tested whether personality moderates type 2 diabetes (T2D) genetic risk. Lower O was associated with higher HbA1c before adjusting for cognitive ability. Association between T2D polygenic risk and HbA1c was stronger in low A and low C. Adjusting for socioeconomic status did not alter the relationships. Personality may influence the genetic tendency to T2D.