Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy.
Metabolic and Biochemical Stressors in Diabetic Cardiomyopathy.
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DOI：
10.3389/fcvm.2017.00031
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发表时间：
2017
影响因子：
3.6
通讯作者：
Halade GV
中科院分区：
文献类型：
--
作者：
Kain V;Halade GV
糖尿病心肌病(DCM)或糖尿病引起的心脏功能障碍是不受控制的代谢综合征的直接后果，在美国人口和世界各地普遍存在。尽管扩张型心肌病具有异质性和明显的特点，但扩张型心肌病的临床相关性现已确立。在糖尿病患者中，扩张型心肌病进展为病理性心脏重构，心脏病发作和继发性心力衰竭的风险更高。在这篇综述中，我们强调脂底物的质量以及DCM在啮齿动物和人类病理生理学中的表型、代谢和生化应激源。我们讨论了炎症途径中的脂氧合酶信号与导致DCM的多种因素和混杂因素。此外，强调新出现的生化途径，以取得治疗进展，以治疗扩张型心肌病。
Diabetic cardiomyopathy (DCM) or diabetes-induced cardiac dysfunction is a direct consequence of uncontrolled metabolic syndrome and is widespread in US population and worldwide. Despite of the heterogeneous and distinct features of DCM, the clinical relevance of DCM is now becoming established. DCM progresses to pathological cardiac remodeling with the higher risk of heart attack and subsequent heart failure in diabetic patients. In this review, we emphasize lipid substrate quality and the phenotypic, metabolic, and biochemical stressors of DCM in the rodent and human pathophysiology. We discuss lipoxygenase signaling in the inflammatory pathway with multiple contributing and confounding factors leading to DCM. Additionally, emerging biochemical pathways are emphasized to make progress toward therapeutic advancement to treat DCM.