Insulin resistance as a predictor of age-related diseases
Insulin resistance as a predictor of age-related diseases
复制标题
DOI：
10.1210/jc.86.8.3574
复制
发表时间：
2001-08-01
影响因子：
5.8
通讯作者：
Raven, GM
中科院分区：
文献类型：
--
作者：
Facchini, FS;Hua, N;Raven, GM
目前的研究是为了评估胰岛素抵抗预测各种年龄相关疾病的能力。在1988-1995年间，对208名明显健康、非肥胖（体重指数< 30 kg/m(2)）的个体进行了胰岛素抵抗和相关变量的基线测量，然后在4-11年后（平均+/- SEM = 6.3 +/- 0.2年）评估以下年龄相关疾病的出现：高血压、冠心病、中风、癌症和2型糖尿病。胰岛素抵抗对临床事件发展的影响通过将研究组分为基线时胰岛素抵抗的四分位数并比较这三组的事件来评估。37人（18%）的临床终点（n = 40）被确定，其中12人患有高血压，3人患有高血压+ 2型糖尿病，9人患有癌症，7人患有冠心病，4人患有中风，2人患有2型糖尿病。在总共40例临床事件中，有28例发生在胰岛素抵抗程度最高的25例个体（36%）中，另外12例发生在胰岛素抵抗程度中等的组中。此外，胰岛素抵抗是所有临床事件的独立预测因子，使用多重逻辑回归和Cox比例风险分析。在基线时，胰岛素抵抗的高1 / 3健康个体中，大约有1 / 3出现了与年龄相关的临床事件，平均随访6年，而在最胰岛素敏感的1 / 3中没有观察到临床事件，这一事实应该成为进一步努力确定胰岛素抵抗在年龄相关疾病发生中的作用的强烈刺激。
The current study was initiated to evaluate the ability of insulin resistance to predict a variety of age-related diseases. Baseline measurements of insulin resistance and related variables were made between 1988-1995 in 208 apparently healthy, nonobese (body mass index < 30 kg/m(2)) individuals, who were then evaluated 4-11 yr later (mean +/- SEM = 6.3 +/- 0.2 yr) for the appearance of the following age-related diseases: hypertension, coronary heart disease, stroke, cancer, and type 2 diabetes. The effect of insulin resistance on the development of clinical events was evaluated by dividing the study group into tertiles of insulin resistance at baseline and comparing the events in these 3 groups. Clinical endpoints (n = 40) were identified in 37 individuals (18%) of those evaluated, including 12 with hypertension, 3 with hypertension + type 2 diabetes, 9 with cancer, 7 with coronary heart disease, 4 with stroke, and 2 with type 2 diabetes. Twenty-eight out of the total 40 clinical events were seen in 25 individuals (36%) in the most insulin-resistant tertile, with the other 12 occurring in the group with an intermediate degree of insulin resistance. Furthermore, insulin resistance was an independent predictor of all clinical events, using both multiple logistic regression and Cox's proportional hazards analysis. The fact that an age-related clinical event developed in approximately 1 out of 3 healthy individuals in the upper tertile of insulin resistance at baseline, followed for an average of 6 yr, whereas no clinical events were observed in the most insulin-sensitive tertile, should serve as a strong stimulus to further efforts to define the role of insulin resistance in the genesis of age-related diseases.