Ten-year alcohol consumption typologies and trajectories of C-reactive protein, interleukin-6 and interleukin-1 receptor antagonist over the following 12 years: a prospective cohort study.
Ten-year alcohol consumption typologies and trajectories of C-reactive protein, interleukin-6 and interleukin-1 receptor antagonist over the following 12 years: a prospective cohort study.
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DOI：
10.1111/joim.12544
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发表时间：
2017-01
影响因子：
11.1
通讯作者：
Britton A
中科院分区：
文献类型：
--
作者：
Bell S;Mehta G;Moore K;Britton A
适度饮酒被认为具有保护心脏代谢的作用。炎症途径被认为是这种关联的部分基础。这项研究的目的是研究饮酒类型和炎症标志物之间的关系，以及它们随时间的变化率。数据来自8209名参与者[69%为男性；平均年龄50岁（SD 6.1）]。在1985年至1994年的大约10年期间，使用多达三种测量方法定义了酒精消费类型：(i)稳定的不饮酒者，（ii）稳定的适度饮酒者（参考），（iii）稳定的重度饮酒者，（iv）不稳定的饮酒者和(v)前饮酒者。在接下来的12年中，C反应蛋白（CRP）、白细胞介素(IL) - 6和IL - 1受体拮抗剂（IL - 1 RA）测量了三次。稳定的适度饮酒者的CRP水平低于稳定的不饮酒者、稳定的重度饮酒者、前饮酒者和不稳定的饮酒者，但两组之间的CRP变化率没有差异。稳定的不饮酒者IL - 6水平高于稳定的重度饮酒者；后一组IL - 6随时间的变化率也有所增加。稳定的不饮酒者也有较高的IL - 1 RA水平。这些关联在校正混杂因素后是稳健的。我们对10年饮酒类型的新研究表明，稳定的适度饮酒与长期炎症标志物相关，这与降低患冠心病的风险一致。
Moderate alcohol consumption is thought to confer cardiometabolic protective effects. Inflammatory pathways are hypothesized to partly underlie this association. The aim of this study was to examine the association between typologies of alcohol consumption and markers of inflammation, and their rate of change over time. Data were collected from 8209 participants [69% men; mean age, 50 years (SD 6.1)] of the British Whitehall II study. Alcohol consumption typologies were defined using up to three measures during an approximately 10‐year period spanning from 1985 to 1994 as (i) stable nondrinkers, (ii) stable moderate drinkers (referent), (iii) stable heavy drinkers, (iv) nonstable drinkers and (v) former drinkers. C‐reactive protein (CRP), interleukin (IL)‐6 and IL‐1 receptor antagonist (IL‐1 RA) were measured up to three times in the following 12 years. Stable moderate drinkers had lower levels of CRP than stable nondrinkers, stable heavy drinkers, former drinkers and nonstable drinkers, but there were no differences in the rate of change in CRP over time between groups. Stable nondrinkers had higher levels of IL‐6 as did stable heavy drinkers; rates of change in IL‐6 over time were also increased in the latter group. Stable nondrinkers also had higher levels of IL‐1 RA. These associations were robust to adjustment for confounding factors. Our novel investigation of 10‐year drinking typologies shows that stable moderate alcohol consumption is associated with a long‐term inflammatory marker profile that is consistent with conferring a reduced risk of developing coronary heart disease.
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影响因子：
7.7
作者：
Carstensen M;Herder C;Kivimäki M;Jokela M;Roden M;Shipley MJ;Witte DR;Brunner EJ;Tabák AG
通讯作者：
Tabák AG
影响因子：
15.8
作者：
Danesh, John;Kaptoge, Stephen;Mann, Andrea G.;Sarwar, Nadeem;Wood, Angela;Angleman, Sara B.;Wensley, Frances;Higgins, Julian P. T.;Lennon, Lucy;Eiriksdottir, Gudny;Rumley, Ann;Whincup, Peter H.;Lowe, Gordon D. O.;Gudnason, Vilmundur
通讯作者：
Gudnason, Vilmundur
Interleukin-1家族：回到未来。
影响因子：
32.4
作者：
Garlanda C;Dinarello CA;Mantovani A
通讯作者：
Mantovani A
影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
DOI：
10.1136/bmj.d636
发表时间：
2011-02-22
期刊：
BMJ (Clinical research ed.)
影响因子：
--
作者：
Brien SE;Ronksley PE;Turner BJ;Mukamal KJ;Ghali WA
通讯作者：
Ghali WA