Pindolol increases extracellular 5-HT while inhibiting serotonergic neuronal activity.
Pindolol increases extracellular 5-HT while inhibiting serotonergic neuronal activity.
复制标题
吲哚洛尔增加细胞外 5-HT，同时抑制血清素能神经元活动。
DOI：
10.1016/s0014-2999(99)00430-6
复制
发表时间：
1999
影响因子：
5
通讯作者：
Jacobs,BL
中科院分区：
文献类型：
--
作者：
Fornal,CA;Martín,FJ;Mendlin,A;Metzler,CW;Bjorvatn,B;Jacobs,BL
在自由活动的猫上，观察了β-肾上腺素受体阻滞剂/5-羟色胺（5-HT）1A/1B拮抗剂吲哚洛尔（pindolol）对中缝背核（dorsal raphe nucleus，DRN）多巴胺能神经元单位放电和尾状核细胞外5-HT含量的影响。施用（±）-吲哚洛尔（1和10 mg/kg，s.c.）神经元活性降低，5-HT水平升高，呈剂量和时间依赖性。随后给予WAY-100635 {N-[2-[4-（2-甲氧基苯基）-1-哌嗪基]乙基]-N-（2-吡啶基）环己烷甲酰胺}（0.2 mg/kg，s.c.），选择性5-HT 1A受体拮抗剂，可阻断吲哚洛尔诱导的神经元抑制并增强5-HT输出。这些结果表明，吲哚洛尔可能在神经末梢水平起作用，以增加5-HT。
The effects of pindolol, a beta-adrenoceptor blocker/putative 5-hydroxytryptamine (5-HT)1A/1Bantagonist, on both the single-unit activity of serotonergic neurons in the dorsal raphe nucleus (DRN) and extracellular 5-HT levels in the caudate nucleus, were examined in freely moving cats. Administration of (±)-pindolol (1 and 10 mg/kg, s.c.) decreased neuronal activity and increased 5-HT levels in a dose- and time-dependent manner. The subsequent administration of WAY-100635 {N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-pyridinyl)cyclohexanecarboxamide} (0.2 mg/kg, s.c.), a selective 5-HT1Areceptor antagonist, blocked pindolol-induced neuronal suppression and potentiated 5-HT output. These results indicate that pindolol may be acting at the level of the nerve terminal to increase 5-HT.