Categorization in the monkey hippocampus: A possible mechanism for encoding information into memory
Categorization in the monkey hippocampus: A possible mechanism for encoding information into memory
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DOI：
10.1073/pnas.0400162101
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发表时间：
2004-03-02
影响因子：
11.1
通讯作者：
Deadwyler, SA
中科院分区：
文献类型：
--
作者：
Hampson, RE;Pons, TP;Deadwyler, SA
哺乳动物的海马体将感觉信息加工成记忆。这种表征的神经生物学基础，以及编码的信息类型，对于理解记忆是如何形成的至关重要。通常，对于任何给定的刺激，都有无限多的信息可以被编码。因此，海马体如何选择和编码给定刺激的特征的问题就出现了。在这里，我们表明，在猴子的海马神经元似乎分类类型的视觉刺激中提出的延迟匹配到样本的记忆任务。通过提取特征的独特组合，这些类别细胞能够编码行为上重要的图像的各个方面，而不是编码所有的视觉细节。然后，当同时出现分散注意力的刺激时，受试者能够快速选择对该刺激的适当反应，从而促进表现。此外，在不同的动物中，这种特定类型的编码差异很大。就像人类一样，不同的猴子关注并选择了同一刺激图像的不同方面，这很可能反映了个体海马体网络中存在的不同历史、策略和期望。
The mammalian hippocampus processes sensory information into memory. The neurobiological basis of this representation, as well as the type of information that is encoded, is central to understanding how memories are formed. Normally, there is an infinite amount of information that could be encoded for any given stimulus. Thus, the question arises as to how the hippocampus selects and encodes features of a given stimulus. Here, we show that neurons in the hippocampus of the monkey appear to categorize types of visual stimuli presented in a delayed-match-to-sample memory task. By extracting unique combinations of features, these category cells are able to encode aspects of behaviorally important images instead of encoding all visual details. The subject is then able to rapidly select an appropriate response to that stimulus when distracting stimuli are presented simultaneously, thereby facilitating performance. Moreover, across animals, this specific type of encoding differed considerably. Just as in humans, different monkeys attended to and selected different aspects of the same stimulus image, most likely reflecting different histories, strategies, and expectations residing within individual hippocampal networks.