A morphological study of the foveal avascular zone in patients with diabetes mellitus using optical coherence tomography angiography
A morphological study of the foveal avascular zone in patients with diabetes mellitus using optical coherence tomography angiography
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DOI：
10.1007/s00417-015-3143-7
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发表时间：
2016-05-01
影响因子：
2.7
通讯作者：
Dong Fangtian
中科院分区：
文献类型：
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作者：
Di, Gong;Yu Weihong;Dong Fangtian
目的应用光学相干断层扫描（OCT）血管造影研究糖尿病（DM）患者中央凹无血管区（FAZ）的面积和半径。方法选取糖尿病患者65例（113眼）和正常人62例（85眼）作为研究对象。所有参与者都接受了OCT血管造影检查。测量了FAZ的垂直半径（VR）、水平半径（HR）和面积。结果对照组与DM组HR、VR、area差异均有统计学意义（p分别为0.01、0.00、0.00）。对照组与非糖尿病视网膜病变（DR）组的HR、VR比较，差异无统计学意义（p = 0.07、0.08），但面积比较，差异有统计学意义（p = 0.04）。与对照组相比，DR患者FAZ的大小更大。HR、VR、area的差异均有统计学意义（p分别= 0.01、0.00、0.00）。此外，临床显著性黄斑水肿（CSME）组FAZ面积也大于非CSME组（p = 0.02）。结论DM患者的FAZ较大，视网膜损伤严重的患者FAZ更大。OCT血管造影是一种方便、无创的研究FAZ的新方法。这种新颖的检查将产生相当数量的数据，不能用以前的研究方法获得。
Purpose To investigate the area and radius of the foveal avascular zone (FAZ) in patients with diabetes mellitus (DM) using optical coherence tomography (OCT) angiography.Methods Sixty-five patients with DM (113 eyes) and 62 healthy controls (85 eyes) were included in the study. All of the participants underwent examination with OCT angiography. The vertical radius (VR), horizontal radius (HR) and area of the FAZ were measured.Results The differences in HR, VR and area between the control and DM groups were statistically significant (p = 0.01, 0.00 and 0.00, respectively). There were no statistically significant differences between the control group and the no-diabetic retinopathy (DR) group in HR or VR (p = 0.07 and 0.08, respectively), but there was a statistically significant difference in area (p = 0.04). The size of the FAZ was greater in patients with DR compared to the control group. The differences in HR, VR and area were statistically significant (p = 0.01, 0.00 and 0.00, respectively). In addition, the clinically significant macular oedema (CSME) group also had a larger FAZ area than the non-CSME group (p = 0.02).Conclusions Patients with DM had a larger FAZ, and patients with more severely damaged retinas had a much larger FAZ. OCT angiography is a new convenient and noninvasive method for studying the FAZ. This novel examination will yield considerable amounts of data that cannot be obtained using previous research methods.