Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy.
Increased levels of anti-PfCSP antibodies in post-pubertal females versus males immunized with PfSPZ Vaccine does not translate into increased protective efficacy.
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在接受PfSPZ疫苗免疫的青春期后女性中，抗PfCSP抗体水平高于男性，但并不能转化为增强保护效果。
DOI：
10.3389/fimmu.2022.1006716
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发表时间：
2022
影响因子：
7.3
通讯作者：
Hoffman, Stephen L.
中科院分区：
文献类型：
--
作者：
Natasha, K. C.;Church, L. W. Preston;Riyahi, Pouria;Chakravarty, Sumana;Seder, Robert A.;Epstein, Judith E.;Lyke, Kirsten E.;Mordmueller, Benjamin;Kremsner, Peter G.;Sissoko, Mahamadou S.;Healy, Sarah;Duffy, Patrick E.;Jongo, Said A.;Nchama, Vicente Urbano Nsue Ndong;Abdulla, Salim;Mpina, Maxmillian;Sirima, Sodiomon B.;Laurens, Matthew B.;Steinhardt, Laura C.;Oneko, Martina;Li, MingLin;Murshedkar, Tooba;Billingsley, Peter F.;Sim, B. Kim Lee;Richie, Thomas L.;Hoffman, Stephen L.
虽然先前的研究表明，男性和女性在疟疾感染和患病的风险方面存在差异，但人们对疫苗引起的疟疾免疫的性别差异知之甚少。确定这些差异可以阐明疟疾生物学的重要方面，并促进开发改进的疟疾疫苗接种方法。在德国、美国和非洲5个国家的11项临床试验中，对5个月至61岁的人接种基于PfSPZ的疟疾疫苗（PfSPZ疫苗）之前和两周后，使用标准化酶联免疫吸附法测量了恶性疟原虫（Pf）孢子虫（SPZ）主要表面蛋白PfCSP的IgG抗体。以确定疫苗引起的抗体反应在男性和女性之间是否存在差异，以及这些差异是否与对自然传播的Pf疟疾（非洲）或受控制的人类疟疾感染（德国、美国和非洲）的不同保护有关。在大多数试验中，年龄≥11岁的女性PfCSP抗体水平明显高于男性，而在婴儿或儿童中没有迹象表明存在这种差异。尽管成年女性的抗体水平较高，但没有证据表明与男性相比，女性的保护能力有所提高。在有足够数据的7项试验中，有2项试验中，受保护的男性的抗体水平明显高于未受保护的男性，在另外3项试验中，受保护的女性的抗体水平高于未受保护的女性。PfSPZ疫苗免疫在青春期后的女性中诱导较高的抗体水平，但在男性和女性中显示出相同的保护作用。我们的结论是，在青春期后的女性中，抗体水平的增加并没有实质性地提高保护作用。我们假设，虽然PfCSP（和PfSPZ）抗体可能直接起到保护作用，但它们主要与其他潜在的保护性免疫机制相关，如肝脏中抗体依赖和抗体独立的细胞反应。
While prior research has shown differences in the risk of malaria infection and sickness between males and females, little is known about sex differences in vaccine-induced immunity to malaria. Identifying such differences could elucidate important aspects of malaria biology and facilitate development of improved approaches to malaria vaccination. Using a standardized enzyme-linked immunosorbent assay, IgG antibodies to the major surface protein on Plasmodium falciparum (Pf) sporozoites (SPZ), the Pf circumsporozoite protein (PfCSP), were measured before and two weeks after administration of a PfSPZ-based malaria vaccine (PfSPZ Vaccine) to 5-month to 61-year-olds in 11 clinical trials in Germany, the US and five countries in Africa, to determine if there were differences in vaccine elicited antibody response between males and females and if these differences were associated with differential protection against naturally transmitted Pf malaria (Africa) or controlled human malaria infection (Germany, the US and Africa). Females ≥ 11 years of age made significantly higher levels of antibodies to PfCSP than did males in most trials, while there was no indication of such differences in infants or children. Although adult females had higher levels of antibodies, there was no evidence of improved protection compared to males. In 2 of the 7 trials with sufficient data, protected males had significantly higher levels of antibodies than unprotected males, and in 3 other trials protected females had higher levels of antibodies than did unprotected females. Immunization with PfSPZ Vaccine induced higher levels of antibodies in post-pubertal females but showed equivalent protection in males and females. We conclude that the increased antibody levels in post-pubertal females did not contribute substantially to improved protection. We hypothesize that while antibodies to PfCSP (and PfSPZ) may potentially contribute directly to protection, they primarily correlate with other, potentially protective immune mechanisms, such as antibody dependent and antibody independent cellular responses in the liver.
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DOI：
10.4269/ajtmh.20-0435
发表时间：
2021-01
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Jongo SA;Urbano V;Church LWP;Olotu A;Manock SR;Schindler T;Mtoro A;Kc N;Hamad A;Nyakarungu E;Mpina M;Deal A;Bijeri JR;Ondo Mangue ME;Ntutumu Pasialo BE;Nguema GN;Owono SN;Rivas MR;Chemba M;Kassim KR;James ER;Stabler TC;Abebe Y;Saverino E;Sax J;Hosch S;Tumbo AM;Gondwe L;Segura JL;Falla CC;Phiri WP;Hergott DEB;García GA;Schwabe C;Maas CD;Murshedkar T;Billingsley PF;Tanner M;Ayekaba MO;Sim BKL;Daubenberger C;Richie TL;Abdulla S;Hoffman SL
通讯作者：
Hoffman SL
影响因子：
3.3
作者：
Jongo, Said A.;Shekalaghe, Seif A.;Hoffman, Stephen L.
通讯作者：
Hoffman, Stephen L.
DOI：
10.4269/ajtmh.21-0899
发表时间：
2021-10-11
期刊：
The American journal of tropical medicine and hygiene
影响因子：
--
作者：
Bell D;Schultz Hansen K
通讯作者：
Schultz Hansen K
影响因子：
3
作者：
Mordmueller, Benjamin;Supan, Christian;Kremsner, Peter G.
通讯作者：
Kremsner, Peter G.
DOI：
10.1073/pnas.1805268115
发表时间：
2018-12-04
影响因子：
11.1
作者：
Fink, Ashley L.;Engle, Kyrra;Klein, Sabra L.
通讯作者：
Klein, Sabra L.