Cell mediated immunity to human myelin basic protein in Vogt-Koyahagi-Harada syndrome.
Cell mediated immunity to human myelin basic protein in Vogt-Koyahagi-Harada syndrome.
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Vogt-Koyahagi-Harada 综合征中细胞介导的对人髓磷脂碱性蛋白的免疫。
DOI：
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发表时间：
1979
影响因子：
4.4
通讯作者：
S. Cohen
中科院分区：
文献类型：
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作者：
R. Manor;E. Livni;S. Cohen
通过人髓鞘碱性蛋白迁移抑制因子技术，寻求Vogt-小柳-原田综合征神经系统受累的免疫学基础。该试验在4名最近表现出该综合征的患者中进行，其中2名在开始类固醇治疗之前和之后进行了评价; 1名患者在从该综合征中恢复4年后进行了评价; 3名患者患有其他原因的葡萄膜炎，以及12名健康对照。结果是积极的，在所有四个病人谁最近的表现，而他们在所有其他人都是阴性的。这一发现可能构成了这种疾病实体中对神经系统成分的细胞介导免疫的证据。
An immunological basis for neurological involvement in Vogt-Koyanagi-Harada syndrome was sought by means of the migration-inhibition factor technique with human myelin basic protein. The test was carried out in four patients who had recent manifestations of the syndrome, two of whom were evaluated both before and after initiation of steroid treatment; in one patient 4 years after recovery from the syndrome; in three patients having uveitis of other causes, and in 12 healthy controls. The results were positive in all four patients who had recent manifestations, whereas they were negative in all the others. This finding may constitute evidence of a cell-mediated immunity toward components of the nervous system in this disease entity.