Cluster Analysis of Circulating Plasma Biomarkers in Prurigo Nodularis Reveals a Distinct Systemic Inflammatory Signature in African Americans.
Cluster Analysis of Circulating Plasma Biomarkers in Prurigo Nodularis Reveals a Distinct Systemic Inflammatory Signature in African Americans.
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DOI：
10.1016/j.jid.2021.10.011
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发表时间：
2022-05
影响因子：
6.5
通讯作者：
Kwatra, Shawn G.
中科院分区：
文献类型：
--
作者：
Sutaria, Nishadh;Alphonse, Martin Prince;Marani, Melika;Parthasarathy, Varsha;Deng, Junwen;Wongvibulsin, Shannon;Williams, Kyle;Roh, Youkyung Sophie;Choi, Justin;Bordeaux, Zachary;Pritchard, Thomas;Dillen, Carly;Semenov, Yevgeniy R.;Kwatra, Madan M.;Archer, Nathan K.;Garza, Luis A.;Dong, Xinzhong;Kang, Sewon;Kwatra, Shawn G.
结节性荨麻疹（PN）患者患有顽固性瘙痒和生活质量急剧下降。虽然PN的表现存在显著的临床异质性，但疾病的内在型仍然未知。我们测定了PN患者（n=20）沿着匹配的健康对照的循环血浆细胞因子浓度，并利用无监督机器学习算法来识别疾病内在型。我们发现两个不同的集群PN患者的非炎症（集群1）和炎症（集群2）血浆配置文件。第2组的非裔美国人较多（82%，n=9 vs. 33%，n=3; P=0.028），最严重瘙痒数字评定量表评分较高（9.5±0.9 vs. 8.3±1.2; P=0.036），生活质量较低，皮肤病生活质量指数评分较高（21.9±6.4 vs. 13.0±4.1; P=0.015）。此外，第1组的脊髓病发生率更高（67%，n=6 vs. 18%，n=2; P=0.028）。与聚类1相比，聚类2具有更高水平的IL-1α、IL-4、IL-5、IL-6、IL-10、IL-17 A、IL-22、IL-25和IFN-α。通过人群水平分析，非裔美国PN患者的红细胞沉降率、C反应蛋白、铁蛋白、嗜酸性粒细胞和转铁蛋白均高于白人PN患者。这些结果表明，PN患者的血浆生物标志物特征与不同的人口统计学和临床特征相对应，可能允许采用精确的医学方法治疗PN。
Patients with prurigo nodularis (PN) suffer from intractable itch and dramatic reduction in quality of life. While there is significant clinical heterogeneity in the presentation of PN, disease endotypes remain unknown. We assayed circulating plasma cytokine concentrations in PN patients (n=20) along with matched healthy controls and utilized an unsupervised machine learning algorithm to identify disease endotypes. We found two distinct clusters of PN patients with non-inflammatory (Cluster 1) and inflammatory (Cluster 2) plasma profiles. Cluster 2 had more African-Americans (82%, n=9 vs. 33%, n=3; P=0.028), higher worst-itch numeric rating scale scores (9.5±0.9 vs. 8.3±1.2; P=0.036), and lower quality of life as reflected by higher Dermatology Life Quality Index scores (21.9±6.4 vs. 13.0±4.1; P=0.015). In addition, Cluster 1 had a higher rate of myelopathy (67%, n=6 vs. 18%, n=2; P=0.028). Compared to Cluster 1, Cluster 2 had higher levels of IL-1α, IL-4, IL-5, IL-6, IL-10, IL-17A, IL-22, IL-25, and IFN-α. With population-level analysis, African-American PN patients had higher erythrocyte sedimentation rate, C-reactive protein, ferritin, eosinophils, and lower transferrin than Caucasian PN patients. These findings indicate discrete clusters of PN patients with plasma biomarker profiles corresponding to distinct demographic and clinical characteristics, potentially allowing for precision medicine approaches to treat PN.
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影响因子：
10.3
作者：
Fukushi, S.;Yamasaki, K.;Aiba, S.
通讯作者：
Aiba, S.
影响因子：
1.8
作者：
Hennig, Christian
通讯作者：
Hennig, Christian
DOI：
10.1073/pnas.42.1.43
发表时间：
1956-01-01
影响因子：
11.1
作者：
ROSENBLATT, M
通讯作者：
ROSENBLATT, M
影响因子：
3
作者：
Johansson, O;Liang, Y;Emtestam, L
通讯作者：
Emtestam, L
影响因子：
4.4
作者：
Haenel, Kai H.;Pfaff, Carolina M.;Baron, Jens M.
通讯作者：
Baron, Jens M.