REDUCED SECRETION OF IGA TO SKIN SURFACE OF PATIENTS WITH ATOPIC-DERMATITIS
REDUCED SECRETION OF IGA TO SKIN SURFACE OF PATIENTS WITH ATOPIC-DERMATITIS
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DOI：
10.1016/0091-6749(94)90040-x
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发表时间：
1994-08-01
影响因子：
14.2
通讯作者：
HORI, Y
中科院分区：
文献类型：
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作者：
IMAYAMA, S;SHIMOZONO, Y;HORI, Y
为了研究特应性皮炎患者皮肤表面分泌型免疫球蛋白A（sIgA）是否减少，通过将纤维素膜盘（10 × 10 mm）贴在上臂皮肤内侧24小时，测定了40例特应性皮炎患者和50例健康志愿者汗液中sIgA的含量。通过使用伊加和分泌组分的抗体的酶免疫测定，将在施用期间被吸收到膜上并积累的伊加的分泌形式显示为点。用密度计测定对应于外分泌管开口的点的密度和数量（每mm（2）/天）。这些患者分泌的sIgA的平均量为3.86 +/- 0.71 pg/mm（2）/天（范围为0至21.17 pg/mm（2）/天），而对照组显著更高（p < 0.001），为16.79 +/- 2.80 pg/mm（2）/天（范围为0.79至133.77 pg/mm（2）/天）。这可能与在特应性皮炎患者中观察到的细菌和病毒皮肤感染的高发病率有关，此外，还与通过去除皮肤过敏原和/或微生物的缺陷而发展成湿疹性病变有关。
To investigate whether the secretory form of immunoglobulin A (sIgA) was reduced on the skin surface in atopic dermatitis, the amount of sIgA present in sweat was measured in 40 patients with atopic dermatitis and in 50 healthy volunteers by attaching a cellulose membrane disk (10 x 10 mm) to the inner aspect of the upper arm skin for 24 hours. The secretory form of IgA, which was absorbed to the membrane and accumulated during the period of application, was revealed as dots by an enzyme immunoassay in which antibodies for IgA and for the secretory component were used. The density and number of dots (per mm(2)/day), which corresponded to the openings of eccrine excretory ducts, were determined with a densitometer. The mean amount of sIgA secreted by those patients was 3.86 +/- 0.71 pg/mm(2)/day (range, 0 to 21.17 pg/mm(2)/day), whereas that of the control subjects was significantly higher (p < 0.001), 16.79 +/- 2.80 pg/mm(2)/day (range, 0.79 to 133.77 pg/mm(2)/day). This may be related to the high incidence of bacterial and viral skin infections seen in patients with atopic dermatitis, and in addition, to the development of eczematous lesions through a defect in ridding the skin of allergens and/or microorganisms.