Detecting biological network organization and functional gene orthologs.
Detecting biological network organization and functional gene orthologs.
复制标题
检测生物网络组织和功能基因直向同源物。
DOI：
10.1093/bioinformatics/btr485
复制
发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Wall,DennisP
中科院分区：
文献类型：
--
作者：
Cui,Jike;DeLuca,ToddF;Jung,Jae-Yoon;Wall,DennisP
摘要：我们基于Roundup开发了一个包TripletSearch来计算基因三元组之间的关系，Roundup是一个包含>；1500基因组的同源基因数据库。这些源于基因协同进化的关系为从局部到系统水平的生物网络组织的检测、蛋白质功能的推断和功能同源基因的鉴定提供了有价值的信息。要进行计算，用户需要提供interest.Availability:http://wall.hms.harvard.edu/sites/default/files/tripletSearch.tar.gzContact:dpwall@hms.harvard.eduSupplementary基因的GI ID信息：补充数据可在生物信息学在线上获得。
SUMMARY:We developed a package TripletSearch to compute relationships within triplets of genes based on Roundup, an orthologous gene database containing >1500 genomes. These relationships, derived from the coevolution of genes, provide valuable information in the detection of biological network organization from the local to the system level, in the inference of protein functions and in the identification of functional orthologs. To run the computation, users need to provide the GI IDs of the genes of interest.Availability:http://wall.hms.harvard.edu/sites/default/files/tripletSearch.tar.gzContact:dpwall@hms.harvard.eduSupplementary Information:Supplementary data are available atBioinformaticsonline.