Effects of methylmercury on the morphogenesis of the rat cerebellum.
Effects of methylmercury on the morphogenesis of the rat cerebellum.
复制标题
甲基汞对大鼠小脑形态发生的影响。
DOI：
10.1002/tera.1420340112
复制
发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Mottet,NK
中科院分区：
文献类型：
--
作者：
Howard,JD;Mottet,NK
在妊娠期和哺乳期，通过母体饮用水连续暴露12.5 ppm甲基汞后，对发育中的大鼠小脑进行了检查。连续暴露导致总小脑细胞群减少，汞组织负荷高于先前的急性剂量研究。细胞坏死不明显，但观察到有丝分裂像模式的改变。甲基汞暴露小脑中细胞数量的减少与有丝分裂早期有丝分裂像数量的增加和中期和晚期有丝分裂像数量的减少有关。这些体内暴露观察结果与体外细胞周期研究一致，在体外细胞周期研究中发现细胞在G2期和早期M期蓄积。细胞增殖受损被认为是持续低剂量接触甲基汞后发育神经毒性的主要机制。
Developing rat cerebellums were examined following continuous methylmercury exposure via maternal drinking water at 12.5 ppm during gestation and the suckling period. The continuous exposure resulted in reductions of the total cerebellar cell population and higher mercury tissue burdens than previous acute‐dose studies. Cell necrosis was not evident, but rather alterations in the pattern of mitotic figures were observed. A decreased number of cells in the methylmercury exposed cerebellums was associated with an increased number of mitotic figures in the early stages of mitosis and a decrease in the number in the middle and late stages. These in vivo exposure observations are consistent with in vitro cell cycle studies in which the cells were found to have accumulated in G2 and early M phases. Impaired cell proliferation is suggested to be a major mechanism of developmental neurotoxicity following continuous low‐does exposure to methylmercury.