Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy
Incidence of immune recovery vitritis in cytomegalovirus retinitis patients following institution of successful highly active antiretroviral therapy
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DOI：
10.1086/314639
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发表时间：
1999-03-01
影响因子：
6.4
通讯作者：
Freeman, WR
中科院分区：
文献类型：
--
作者：
Karavellas, MP;Plummer, DJ;Freeman, WR
这项研究是为了确定一种新的眼部炎症综合征(免疫恢复性玻璃体炎，IRV)的可能性，这种综合征会导致对高效抗逆转录病毒治疗(HAART)有效的巨细胞病毒(CMV)视网膜炎艾滋病患者的视力丧失。我们跟踪了30名CD4细胞计数大于或等于60细胞/毫米的HAART应答者。如果患者发展为s1的症状性玻璃体炎，则诊断为IRV；严重程度与非活动性CMV视网膜炎相关，30例患者中19例(63%)出现症状性IRV，44只眼中26例(59%)在HAART反应13.5个月的中位随访期内发生。IRV年发病率为83/100人年。排除了以前接受西多福韦治疗的患者，IRV的时间进程没有显著改变(P=.79)，这些数据表明，IRV在相当数量的CMV视网膜炎的HAART应答者中发生，与以前的西多福韦治疗无关。
This study was conducted to determine the likelihood of the development of a new ocular inflammatory syndrome (immune recovery vitritis, IRV), which causes vision loss in AIDS patients with cytomegalovirus (CMV) retinitis, who respond to highly active antiretroviral therapy (HAART), We followed 30 HAART-responders with CD4 cell counts of greater than or equal to 60 cells/mm(3). Patients were diagnosed with IRV if they developed symptomatic vitritis of sl; severity associated with inactive CMV retinitis, Symptomatic IRV developed in 19 (63%) of 30 patients and in 26 (59%) of 44 eyes over a median follow-up from HAART response of 13.5 months. The annual incidence of IRV was 83/100 person-years. Excluding patients with previous cidofovir therapy did not significantly alter the time course of IRV (P = .79), These data suggest that IRV develops in a significant number of HAART-responders with CMV retinitis and is unrelated to previous cidofovir therapy.