Measuring and estimating insulin resistance in clinical and research settings.
Measuring and estimating insulin resistance in clinical and research settings.
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在临床和研究环境中测量和估计胰岛素抵抗。
DOI：
10.1002/oby.23503
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发表时间：
2022-08
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本文讨论了如何测量人体肌肉、肝脏和脂肪组织中的胰岛素抵抗。详细描述了评估胰岛素抵抗最常用的方法，从金标准，即正糖高胰岛素钳，到静脉葡萄糖耐量试验，基于禁食测量的替代指标，或动态试验（如口服葡萄糖或混合膳食耐量试验）。报告了测试的准确度、精密度和再现性以及截止值。
The article discusses how to measure insulin resistance in muscle, liver, and adipose tissue in human participants. The most frequently used methodologies to evaluate insulin resistance are described in detail starting from the gold standard, that is, the euglycemic hyperinsulinemic clamp, to the intravenous glucose tolerance test, surrogate indices based on fasting measurements, or dynamic tests (such as oral glucose or mixed meal tolerance tests). The accuracy, precision, and reproducibility of the tests as well as cutoff values are reported.