Myrotheciumones: Bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens
Myrotheciumones: Bicyclic cytotoxic lactones isolated from an endophytic fungus of Ajuga decumbens
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DOI：
10.1016/j.bmcl.2014.04.016
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发表时间：
2014-06-01
影响因子：
2.7
通讯作者：
Chen, Haifeng
中科院分区：
文献类型：
--
作者：
Lin, Ting;Wang, Guanghui;Chen, Haifeng
从疣漆斑菌（Myrotheciumroridum）中分离得到两个新的双环内酯化合物：漆斑菌酮A（1）和B（2），它们具有罕见的环融合系统。roridum）为药用植物筋骨草（Ajuga decumbens（A.斜卧草属）。从1D和2D NMR（核磁共振）数据推断结构。对漆斑菊酮A的体外细胞毒活性和凋亡活性进行了评价，并显示漆斑菊酮A通过诱导癌细胞系的凋亡而发挥细胞毒作用。(C)2014爱思唯尔有限公司版权所有。
Two new bicyclic lactones, myrotheciumones A (1) and B (2) which possessed a rare ring-fusion system were isolated from Myrothecium roridum (M. roridum), an endophytic fungus of the medicinal herb plant Ajuga decumbens (A. decumbens) via an in vitro cytotoxicity assay. Structures were deduced from 1D and 2D NMR (Nuclear magnetic resonance) data. Myrotheciumone A's in vitro cytotoxicity and apoptotic activity were evaluated and myrotheciumone A was shown to exert cytotoxicity via inducing apoptosis in cancer cell line. (C) 2014 Elsevier Ltd. All rights reserved.