The evidence to date: A redox-inactive analogue of tocotrienol as a new anti-mesothelioma agent
The evidence to date: A redox-inactive analogue of tocotrienol as a new anti-mesothelioma agent
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DOI：
10.29245/2572-9411/2017/1.1072
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
T. Yano
中科院分区：
文献类型：
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作者：
T. Yano
恶性间皮瘤（MM）是一种与接触石棉有关的侵袭性癌症。近年来，尽管石棉的使用受到限制，但由于其潜伏期长，MM的发病率一直在增加。由于其预后不良，MM的治疗需要创新疗法。生育三烯酚（T3）是维生素E类似物之一，具有强大的抗氧化特性和抗癌作用。然而，这些影响尚未完全了解，并介导独立的抗氧化活性。因此，我们合成了一种新的T3的氧化还原非活性衍生物（T3E），其显示出比其氧化还原敏感的母体化合物更强的抗MM作用。本文就T3的非抗氧化功能T3 E抗MM作用的研究进展作一综述。
Malignant mesothelioma (MM) is an aggressive cancer associated with exposure to asbestos. In recent years, despite restrictions on the use of asbestos, the incidence of MM has been increasing due to its long latency period. Owing to its poor prognosis, the treatment of MM requires innovative therapies. Tocotrienol (T3), one of the vitamin E analogues, has powerful antioxidant properties and anti-cancer effects. However, these effects have not been fully understood, and are mediated independent of its antioxidant activity. Therefore, we have synthesized a new redox-inactive derivative of T3 (T3E), that has shown a stronger anti-MM effect than its redox-sensitive mother compound. In this review, we discuss the potential for anti-MM effect of T3E as non-antioxidant functions of T3 by introducing our previous reports.