Biological and analytical stability of a peripheral blood gene expression score for obstructive coronary artery disease in the PREDICT and COMPASS studies.
Biological and analytical stability of a peripheral blood gene expression score for obstructive coronary artery disease in the PREDICT and COMPASS studies.
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DOI：
10.1007/s12265-014-9583-3
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发表时间：
2014-10
影响因子：
3.4
通讯作者：
Rosenberg, Steven
中科院分区：
文献类型：
--
作者：
Daniels, Susan E.;Beineke, Philip;Rhees, Brian;McPherson, John A.;Kraus, William E.;Thomas, Gregory S.;Rosenberg, Steven
阻塞性冠状动脉疾病（CAD）的基因表达评分（GES）已在两项多中心研究中得到验证。冠状动脉树（PREDICT）队列扩展个性化风险评价和诊断的GES受试者工作特征（ROC）分析（NCT编号00500617），通过定量冠状动脉造影术（QCA）或临床读数定义的CAD患者产生了相似的性能（曲线下面积（AUC）= 0.70，N = 1，502）与原始验证组（AUC = 0.70，N = 526）的差异。对138例非高加索人和1，364例高加索人患者的分析显示出非常相似的性能（AUC = 0.72 vs. 0.70）。为了评估分析稳定性，在5年后重新检测了原始验证队列（N = 526）的储存样本，5年后平均评分从20.3变为19.8（N = 501，95%）。为了评估患者评分随时间的变化，在入组后约1年时，对来自173例通过分子个性化基因表达进行冠状动脉阻塞检测（COMPASS）研究（NCT编号01117506）患者的样本测定GES。平均评分从15.9略微增加至17.3，对应于阻塞性CAD可能性增加2.5%。心血管药物的变化未显示GES的显著变化。本文的在线版本（doi：10.1007/s12265-014-9583-3）包含补充材料，可供授权用户使用。
A gene expression score (GES) for obstructive coronary artery disease (CAD) has been validated in two multicenter studies. Receiver-operating characteristics (ROC) analysis of the GES on an expanded Personalized Risk Evaluation and Diagnosis in the Coronary Tree (PREDICT) cohort (NCT no. 00500617) with CAD defined by quantitative coronary angiography (QCA) or clinical reads yielded similar performance (area under the curve (AUC) = 0.70, N = 1,502) to the original validation cohort (AUC = 0.70, N = 526). Analysis of 138 non-Caucasian and 1,364 Caucasian patients showed very similar performance (AUCs = 0.72 vs. 0.70). To assess analytic stability, stored samples of the original validation cohort (N = 526) was re-tested after 5 years, and the mean score changed from 20.3 to 19.8 after 5 years (N = 501, 95 %). To assess patient scores over time, GES was determined on samples from 173 Coronary Obstruction Detection by Molecular Personalized Gene Expression (COMPASS) study (NCT no. 01117506) patients at approximately 1 year post-enrollment. Mean scores increased slightly from 15.9 to 17.3, corresponding to a 2.5 % increase in obstructive CAD likelihood. Changes in cardiovascular medications did not show a significant change in GES. The online version of this article (doi:10.1007/s12265-014-9583-3) contains supplementary material, which is available to authorized users.
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影响因子：
3.7
作者：
Sinicropi D;Qu K;Collin F;Crager M;Liu ML;Pelham RJ;Pho M;Dei Rossi A;Jeong J;Scott A;Ambannavar R;Zheng C;Mena R;Esteban J;Stephans J;Morlan J;Baker J
通讯作者：
Baker J
影响因子：
4.1
作者：
Debey-Pascher, Svenja;Hofmann, Andrea;Staratschek-Jox, Andrea
通讯作者：
Staratschek-Jox, Andrea
影响因子：
39.2
作者：
Rosenberg S;Elashoff MR;Beineke P;Daniels SE;Wingrove JA;Tingley WG;Sager PT;Sehnert AJ;Yau M;Kraus WE;Newby LK;Schwartz RS;Voros S;Ellis SG;Tahirkheli N;Waksman R;McPherson J;Lansky A;Winn ME;Schork NJ;Topol EJ;PREDICT (Personalized Risk Evaluation and Diagnosis in the Coronary Tree) Investigators
通讯作者：
PREDICT (Personalized Risk Evaluation and Diagnosis in the Coronary Tree) Investigators
影响因子：
3.7
作者：
Elashoff, Michael R.;Nuttall, Rachel;Wingrove, James A.
通讯作者：
Wingrove, James A.
影响因子：
4.8
作者：
Lansky, Alexandra;Elashoff, Michael R.;Topol, Eric J.
通讯作者：
Topol, Eric J.