Cytokines and beyond: Regulation of innate immune responses during helminth infection.
Cytokines and beyond: Regulation of innate immune responses during helminth infection.
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DOI：
10.1016/j.cyto.2018.08.021
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发表时间：
2020-09
期刊：
影响因子：
3.8
通讯作者：
Tait Wojno ED
中科院分区：
文献类型：
--
作者：
Oyesola OO;Früh SP;Webb LM;Tait Wojno ED
寄生蠕虫感染诱发2型胆碱介导的炎症反应。在2型炎症期间，暴露于蠕虫及其产物的受损或刺激的上皮细胞产生警报素和细胞因子，包括IL-25、IL-33和胸腺基质淋巴细胞生成素。这些因子促进支持CD 4 + T辅助2型（Th 2）细胞极化的先天免疫细胞活化。激活的先天性和Th 2细胞产生细胞因子IL-4、-5、-9和-13，这些细胞因子使免疫激活永久化，并作用于上皮细胞，驱动杯状细胞增生和增加上皮细胞更新。这些事件共同驱动蠕虫排出和伤口愈合过程。虽然Th 2细胞在这种情况下的作用已被大量研究，但最近的工作表明，上皮细胞衍生的细胞因子是关键的先天免疫应答的驱动因素，这对2型抗蠕虫应答至关重要。尖端研究已经开始全面评估其他因素和途径，包括脂质介质，趋化因子，Fc受体信号传导，ESTA相关分子模式分子和直接细胞-细胞相互作用，也参与形成先天性细胞介导的2型炎症。在这篇综述中，我们讨论了这些途径如何交叉和协同上皮细胞源性细胞因子控制的途径，以协调驱动蠕虫诱导的2型炎症的先天免疫反应。
Parasitic helminth infection elicits a type 2 cytokine-mediated inflammatory response. During type 2 inflammation, damaged or stimulated epithelial cells exposed to helminths and their products produce alarmins and cytokines including IL-25, IL-33, and thymic stromal lymphopoietin. These factors promote innate immune cell activation that supports the polarization of CD4+ T helper type 2 (Th2) cells. Activated innate and Th2 cells produce the cytokines IL-4, −5, −9, and −13 that perpetuate immune activation and act back on the epithelium to drive goblet cell hyperplasia and increased epithelial cell turnover. Together, these events drive worm expulsion and wound healing processes. While the role of Th2 cells in this context has been heavily studied, recent work has revealed that epithelial cell-derived cytokines are drivers of key innate immune responses that are critical for type 2 anti-helminth responses. Cutting-edge studies have begun to fully assess how other factors and pathways, including lipid mediators, chemokines, Fc receptor signaling, danger-associated molecular pattern molecules, and direct cell-cell interactions, also participate in shaping innate cell-mediated type 2 inflammation. In this review, we discuss how these pathways intersect and synergize with pathways controlled by epithelial cell-derived cytokines to coordinate innate immune responses that drive helminth-induced type 2 inflammation.
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影响因子：
3.7
作者：
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通讯作者：
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16.6
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影响因子：
14.2
作者：
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影响因子：
14.2
作者：
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通讯作者：
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