Malic enzyme 2 promotes the progression of hepatocellular carcinoma via increasing triglyceride production.
Malic enzyme 2 promotes the progression of hepatocellular carcinoma via increasing triglyceride production.
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苹果酸酶2通过增加甘油三酯的产生促进肝细胞癌的进展
DOI：
10.1002/cam4.4209
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发表时间：
2021-10
期刊：
影响因子：
4
通讯作者：
Zhou S
中科院分区：
文献类型：
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作者：
Zhang S;Cheng ZM;Yu JL;Lu K;Xu SJ;Lu Y;Liu T;Xia BJ;Huang Z;Zhao XY;He W;Li JX;Cao W;Huang Y;Wang L;Zeng Z;Zou X;Liu R;Zhang YS;Wu XP;Jiang TP;Zhou S
近年来，肝细胞癌（hepatocellular carcinoma，HCC）的发病率和死亡率逐渐增高.近年来，有研究报道苹果酸酶（ME）在肿瘤发生发展中起重要作用，但ME 2在肝癌中的作用尚不明确。在这里，我们证明了ME2在HCC中发挥致癌作用。ME2在肝癌组织中呈高表达。TCGA数据库显示，ME2转录水平与HCC患者的生存率呈负相关。功能丧失和功能获得试验表明，ME2促进HCC细胞生长和迁移。此外，ME2基因敲低可延缓MHCC 97 H细胞的异种移植瘤发生。ME2沉默还抑制细胞周期进程并诱导凋亡。机制上，ME2增强甘油三酯合成，抑制其抑制增殖和迁移。我们认为ME2通过增加甘油三酯的产生来促进HCC的进展。
The incidence and mortality of hepatocellular carcinoma (HCC) are gradually increasing during the past years. Recently, some studies have reported that malic enzyme (ME) plays an important role in cancer development, while the involvement of ME2 in HCC remains still undetermined. Here, we demonstrated that ME2 played an oncogenic role in HCC. ME2 was overexpressed in HCC tissues. TCGA database showed that the ME2 transcript level was inversely associated with the survival of HCC patients. Loss‐of‐function and gain‐of‐function assays showed that ME2 promoted HCC cell growth and migration. Furthermore, the xenografted tumorigenesis of MHCC97H cells was retarded by ME2 knockdown. ME2 silencing also suppressed the cell cycle process and induced apoptosis. Mechanistically, ME2 potentiated triglyceride synthesis, inhibition of which suppressed the proliferation and migration. We propose that ME2 promotes HCC progression by increasing triglyceride production.
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