Fundamental study of ultrasonic-measurement-integrated simulation of real blood flow in the aorta
Fundamental study of ultrasonic-measurement-integrated simulation of real blood flow in the aorta
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DOI：
10.1007/s10439-005-2495-2
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发表时间：
2005-04-01
影响因子：
3.8
通讯作者：
Yambe, T
中科院分区：
文献类型：
--
作者：
Funamoto, K;Hayase, T;Yambe, T
获取血流速度和压力场的详细信息对于准确诊断或治疗主动脉瘤等严重循环系统疾病至关重要。获得此类信息的一种可能方法是将数值模拟和彩色多普勒超声检查集成在血流观测器的框架中。该方法，即超声波测量集成（UMI）模拟，由以下过程组成。在数值模拟的每个时间步长，评估可测量的输出信号与数值模拟指示的信号之间的差异。根据差异生成反馈信号，并应用反馈信号更新数值模拟以补偿差异。本文利用简单的二维模型问题对带有动脉瘤的主动脉中的血流进行 UMI 模拟基本特征的数值研究。系统地研究了反馈点数和反馈公式的影响。结果表明，即使上游边界条件通常不可避免地存在错误，反馈域中的 UMI 仿真结果也会快速收敛到标准解。最后，带有真实彩色多普勒测量反馈的 UMI 模拟示例也显示出与测量的良好一致性。
Acquisition of detailed information on the velocity and pressure fields of the blood flow is essential to achieve accurate diagnosis or treatment for serious circulatory diseases such as aortic aneurysms. A possible way to obtain such information is integration of numerical simulation and color Doppler ultrasonography in the framework of a flow observer. This methodology, namely, Ultrasonic-Measurement-Integrated (UMI) Simulation, consists of the following processes. At each time step of numerical simulation, the difference between the measurable output signal and the signal indicated by numerical simulation is evaluated. Feedback signals are generated from the difference, and numerical simulation is updated applying the feedback signal to compensate for the difference. This paper deals with a numerical study on the fundamental characteristics of UMI simulation using a simple two-dimensional model problem for the blood flow in an aorta with an aneurysm. The effect of the number of feedback points and the feedback formula are investigated systematically. It is revealed that the result of UMI simulation in the feedback domain rapidly converges to the standard solution, even with usually inevitable incorrect upstream boundary conditions. Finally, an example of UMI simulation with feedback from real color Doppler measurement also shows a good agreement with measurement.