Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands
Homeostatic expansion and phenotypic conversion of naive T cells in response to self peptide/MHC ligands
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DOI：
10.1073/pnas.96.23.13306
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发表时间：
1999-11-09
影响因子：
11.1
通讯作者：
Jameson, SC
中科院分区：
文献类型：
--
作者：
Kieper, WC;Jameson, SC
最近的数据表明，静止的幼稚T细胞的生存需要与自身MHC分子的相互作用。通过对I类MHC限制性T细胞受体转基因株OT-1的分析。我们报告了一个不同的反应。这些T细胞不是仅仅存活，而是在转移到T耗尽的同基因宿主后缓慢增殖。这种扩张既需要T细胞的“空间”，也需要自身I类MHC分子正常水平的表达。此外，我们证明在适当环境中的动态平衡扩张期间，尽管没有外来抗原刺激，幼稚表型(CD44(低))OT-1T细胞转化为记忆表型(CD44(中/高))。另一方面，内稳态扩张的细胞没有获得细胞溶解效应功能。这些数据对T细胞与自身多肽/MHC配体的反应性的意义，以及对正常和异常T细胞稳态的影响进行了讨论。
Recent data suggest that survival of resting, naive T cells requires an interaction with self MHC molecules. From analysis of the class I MHC-restricted T cell receptor transgenic strain OT-1. we report a different response. Rather than merely surviving, these T cells proliferated slowly after transfer into T-depleted syngeneic hosts. This expansion required both T cell "space" and expression of normal levels of self class I MHC molecules. Furthermore, we demonstrate that during homeostatic expansion in a suitable environment, naive phenotype (CD44(low)) OT-1 T cells converted to memory phenotype (CD44(med/high)), despite the absence of foreign antigenic stimulation. On the other hand, cells undergoing homeostatic expansion did not acquire cytolytic effector function. The significance of these data for reactivity of T cells with self peptide/MHC ligands and the implications for normal and abnormal T cell homeostasis are discussed.