Trafficking and Cell Migration
Trafficking and Cell Migration
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DOI：
10.1111/j.1600-0854.2009.00929.x
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发表时间：
2009-07-01
期刊：
影响因子：
4.5
通讯作者：
Heisenberg, Carl-Philipp
中科院分区：
文献类型：
--
作者：
Ulrich, Florian;Heisenberg, Carl-Philipp
单细胞和上皮片的迁移对于发育中胚胎的原肠胚形成和器官形成非常重要，如果调节不当，可能会产生可怕的后果，例如在癌症转移期间。细胞迁移的关键是粘附接触的调节，粘附接触通过内吞作用动态组装和拆卸。在这里，我们讨论细胞迁移过程中内吞运输功能的一些基本概念：整合素从细胞后部运输到成纤维细胞前缘；通过生长因子的内吞运输将信号传导限制在单细胞的前端；通过钙粘蛋白周转调节多细胞片中的运动连贯性；和细胞外趋化因子梯度的形成。总而言之，内吞作用使迁移细胞和组织能够动态调节它们的粘附和信号传导，使它们能够有效地迁移通过细胞外环境。
The migration of single cells and epithelial sheets is of great importance for gastrulation and organ formation in developing embryos and, if misregulated, can have dire consequences e.g. during cancer metastasis. A keystone of cell migration is the regulation of adhesive contacts, which are dynamically assembled and disassembled via endocytosis. Here, we discuss some of the basic concepts about the function of endocytic trafficking during cell migration: transport of integrins from the cell rear to the leading edge in fibroblasts; confinement of signalling to the front of single cells by endocytic transport of growth factors; regulation of movement coherence in multicellular sheets by cadherin turnover; and shaping of extracellular chemokine gradients. Taken together, endocytosis enables migrating cells and tissues to dynamically modulate their adhesion and signalling, allowing them to efficiently migrate through their extracellular environment.