Mosaic arrangement of ganglion cell receptive fields in rabbit retina
Mosaic arrangement of ganglion cell receptive fields in rabbit retina
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DOI：
10.1152/jn.1997.78.4.2048
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发表时间：
1997-10-01
影响因子：
2.5
通讯作者：
Baylor, DA
中科院分区：
文献类型：
--
作者：
DeVries, SH;Baylor, DA
视网膜表面上神经节细胞感受野的排列应该限制视觉的几个特性，包括空间分辨率。对哺乳动物视网膜的解剖学和生理学研究表明，几种类型的神经节细胞的感受野平铺视网膜表面，不同类别的感受野重叠程度显然相似。然而，很难测试这种安排的通用性，因为用传统的单单位记录很难在同一个制备中对许多感受野进行采样。在我们的实验中，多达80个相邻的神经节细胞在离体兔视网膜的反应特性和感受野的特点，同时记录与多电极阵列。根据细胞的特征光反应和脉冲序列的时间结构，将细胞分为11类。在用广义高斯曲面拟合每个感受野的空间轮廓后，检查给定类别的细胞的感受野的镶嵌布置。对于八个细胞类的马赛克安排是相似的：相邻细胞的配置文件彼此接近的I-A边界。因此，场中心相距2 sigma。其余三个类别的场的布局没有很好地表征，因为场不适合单个高斯或因为细胞选择性地对运动做出反应。2 σ中心-中心间距可以是功能组织的一般原则，其最小化空间混叠并赋予神经节细胞群体均匀的空间灵敏度。
The arrangement of ganglion cell receptive fields on the retinal surface should constrain several properties of vision, including spatial resolution. Anatomic and physiological studies on the mammalian retina have shown that the receptive fields of several types of ganglion cells tile the retinal surface, with the degree of receptive field overlap apparently being similar for the different classes. It has been difficult to test the generality of this arrangement, however, because it is hard to sample many receptive fields in the same preparation with conventional single-unit recording. In our experiments, the response properties and receptive fields of up to 80 neighboring ganglion cells in the isolated rabbit retina were characterized simultaneously by recording with a multielectrode array. The cells were divided into 11 classes on the basis of their characteristic light responses and the temporal structures of their impulse trains. The mosaic arrangement of receptive fields for cells of a given class was examined after the spatial profile of each receptive field was fitted with a generalized Gaussian surface. For eight cell classes the mosaic arrangement was similar: the profiles of neighboring cells approached each other at the I-a border. Thus field centers were 2 sigma apart. The layout of fields for the remaining three classes was not well characterized because the fields were poorly fitted by a single Gaussian or because the cells responded selectively to movement. The 2-sigma center-center spacing may be a general principle of functional organization that minimizes spatial aliasing and confers a uniform spatial sensitivity on the ganglion cell population.