Antenatal and postpartum depressive symptoms are differentially associated with early childhood weight and adiposity
Antenatal and postpartum depressive symptoms are differentially associated with early childhood weight and adiposity
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DOI：
10.1111/j.1365-3016.2010.01098.x
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发表时间：
2010-03-01
影响因子：
2.8
通讯作者：
Gillman, Matthew W.
中科院分区：
文献类型：
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作者：
Ertel, Karen A.;Koenen, Karestan C.;Gillman, Matthew W.
P>；Ertel Ka，Koenen KC，Rich-Edwards JW，Gillman MW。产前和产后抑郁症状与儿童早期体重和肥胖症有不同的关联。儿科和围产期流行病学2010；24：179-189。产前抑郁与小于胎龄有关，但很少有研究检查与儿童时期体重的关系。同样，很少有研究探讨产前和产后抑郁是否会对孩子的体重产生不同影响。在前瞻性队列研究Project Viva中的838对母子二人组中，我们调查了产前和产后抑郁与儿童体重和肥胖的关系。我们在孕中期和产后6个月使用爱丁堡产后抑郁量表(得分>；=13，表示可能患有抑郁症)来评估母亲的抑郁。我们在3岁时评估了儿童的结果：体重指数(BMI)z分数，身高体重z分数，肩峰下(SS)和三头肌(TR)皮褶厚度之和(SS+TR)，以及SS/TR比率，对于中心性肥胖。69名(8.2%)女性经历了产前抑郁，59名(7.0%)产后抑郁。3岁时的平均(SD)结果为：BMI z-Score，0.45(1.01)；SS+Tr16.72(4.03)mm；SS：Tr0.64(0.15)。在多变量模型中，产前抑郁与较低的儿童BMI z得分(-0.24[95%可信区间：-0.49，0.00])相关，但与较高的SS：TR值(0.05[0.01，0.09])相关。没有证据表明产前抑郁和这些结果之间存在剂量-反应关系。产后抑郁与较高的SS+TR值相关(1.14[0.11，2.18])。总而言之，在3岁时，产前抑郁与体型较小和中心性肥胖有关，而产后抑郁与总体肥胖率较高有关。
P>Ertel KA, Koenen KC, Rich-Edwards JW, Gillman MW. Antenatal and postpartum depressive symptoms are differentially associated with early childhood weight and adiposity. Paediatric and Perinatal Epidemiology 2010; 24: 179-189.Antenatal depression is associated with small-for-gestational age, but few studies have examined associations with weight during childhood. Similarly, few studies address whether antenatal and postpartum depression differentially affect child weight. Among 838 mother-child dyads in Project Viva, a prospective cohort study, we examined relationships of antenatal and postpartum depression with child weight and adiposity. We assessed maternal depression at mid-pregnancy and 6 months postpartum with the Edinburgh Postnatal Depression Scale (score >= 13 indicating probable depression). We assessed child outcomes at age 3 years: body mass index (BMI) z-score, weight-for-height z-score, sum of subscapular (SS) and triceps (TR) skinfold thickness (SS + TR) for overall adiposity, and SS : TR ratio for central adiposity.Sixty-nine (8.2%) women experienced antenatal depression and 59 (7.0%) postpartum depression. Mean (SD) outcomes at age 3 were: BMI z-score, 0.45 (1.01); SS + TR, 16.72 (4.03) mm; SS : TR, 0.64 (0.15). In multivariable models, antenatal depression was associated with lower child BMI z-score (-0.24 [95% confidence interval: -0.49, 0.00]), but higher SS : TR (0.05 [0.01, 0.09]). There was no evidence of a dose-response relationship between antenatal depression and these outcomes. Postpartum depression was associated with higher SS + TR (1.14 [0.11, 2.18]). In conclusion, whereas antenatal depression was associated with smaller size and central adiposity at age 3 years, postpartum depression was associated with higher overall adiposity.