Caffeine in human milk and in serum of breast-fed infants.
Caffeine in human milk and in serum of breast-fed infants.
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DOI：
10.1159/000457057
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发表时间：
1985
期刊：
影响因子：
--
通讯作者：
J. Ryu
中科院分区：
文献类型：
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作者：
J. Ryu
本研究测定了已知咖啡因摄入量的哺乳期妇女乳汁中的咖啡因浓度，并测定了其婴儿的血清咖啡因浓度。对9名哺乳期妇女及其婴儿进行了为期9天的研究。在最初的5天里，这些女性每天摄入750毫克咖啡因，在接下来的4天里，她们不摄入咖啡因，避免喝咖啡和其他含咖啡因的产品。在研究的第一天，7名分娩后11-22天的母亲在第5天将每次喂养的等分试样合并获得的乳汁样品中咖啡因的浓度平均为4.3微克/毫升。数值范围为不可检测（小于0.25微克/毫升）至15.7微克/毫升。在第9天获得的牛奶样品中未检测到咖啡因。第5天婴儿血清中咖啡因的平均浓度为1.4微克/毫升（范围：无法检测到2.8微克/毫升）。在第9天获得的2名婴儿血清中仍可检测到咖啡因。自第5天以来，浓度仅略有下降。如所述研究2个较大的婴儿和他们的母亲，不同的是在第5天和第9天从每次喂养中获得乳汁样品并单独分析。第5天摄入的牛奶中的平均咖啡因浓度分别为13.4和28.6微克/毫升。第5天婴儿血清中的咖啡因浓度低于0.25和3.2微克/毫升。在第9天，牛奶和血清咖啡因水平低于检测限。
A study was carried out to determine the caffeine concentration in milk of lactating women ingesting known amounts of caffeine and to determine serum concentration of caffeine of their infants. 9 lactating women and their infants were studied for 9 days. For the first 5 days, the women ingested 750 mg of caffeine daily, and for the next 4 days they ingested no caffeine and avoided coffee and other caffeine-containing products. The concentration of caffeine in samples of milk obtained by pooling aliquots from each feeding on day 5 averaged 4.3 micrograms/ml for 7 mothers who were 11-22 days after delivery on the 1st day of study. Values ranged from nondetectable (less than 0.25 micrograms/ml) to 15.7 micrograms/ml. No caffeine was detected in milk samples obtained on day 9. The mean concentration of caffeine in sera of the infants on day 5 was 1.4 micrograms/ml (range: nondetectable to 2.8 micrograms/ml). Caffeine was still detectable in 2 infants' sera obtained on day 9. Concentrations had decreased only slightly since day 5. 2 older infants and their mothers were studied as described except that on days 5 and 9 samples of milk were obtained from each feeding and analyzed individually. The average caffeine concentrations in milk consumed on day 5 were 13.4 and 28.6 micrograms/ml, respectively. The concentrations of caffeine in infants' sera on day 5 were less than 0.25 and 3.2 micrograms/ml. On day 9 milk and serum caffeine levels were below the limits of detectability.