Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach
Development of epitope-based peptide vaccine against novel coronavirus 2019 (SARS-COV-2): Immunoinformatics approach
复制标题
DOI：
10.1002/jmv.25736
复制
发表时间：
2020-06-01
影响因子：
12.7
通讯作者：
Chakraborty, Chiranjib
中科院分区：
文献类型：
--
作者：
Bhattacharya, Manojit;Sharma, Ashish R.;Chakraborty, Chiranjib
最近，一种新型冠状病毒（SARS-COV-2）出现，这是最近在中国武汉爆发的原因。在遗传学上，它与SARS-CoV和MERS-CoV密切相关。因此，迫切需要设计一种合适的SARS-COV-2多肽疫苗组分。在这里，我们的特点刺糖蛋白，以获得免疫原性表位。接下来，我们选择了具有抗原特性的13个主要组织相容性复合物-（MHC）I和3个MHC-II表位。这些表位通常与特定的接头连接以构建疫苗组分，并与toll样受体-5分子对接以获得结合亲和力。因此，为了提供这些表位的快速免疫原性谱，我们进行了免疫信息学分析，以便疫苗的快速开发可能会使这种灾难性的情况更早结束。
Recently, a novel coronavirus (SARS-COV-2) emerged which is responsible for the recent outbreak in Wuhan, China. Genetically, it is closely related to SARS-CoV and MERS-CoV. The situation is getting worse and worse, therefore, there is an urgent need for designing a suitable peptide vaccine component against the SARS-COV-2. Here, we characterized spike glycoprotein to obtain immunogenic epitopes. Next, we chose 13 Major Histocompatibility Complex-(MHC) I and 3 MHC-II epitopes, having antigenic properties. These epitopes are usually linked to specific linkers to build vaccine components and molecularly dock on toll-like receptor-5 to get binding affinity. Therefore, to provide a fast immunogenic profile of these epitopes, we performed immunoinformatics analysis so that the rapid development of the vaccine might bring this disastrous situation to the end earlier.