Revving the Throttle on an oncogene: CDK8 takes the driver seat.
Revving the Throttle on an oncogene: CDK8 takes the driver seat.
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DOI：
10.1158/0008-5472.can-09-1704
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发表时间：
2009-10-15
期刊：
影响因子：
11.2
通讯作者：
Hahn WC
中科院分区：
文献类型：
--
作者：
Firestein R;Hahn WC
Wnt/β-连环蛋白通路在大多数（如果不是全部）结肠癌的起始中起重要作用。先前的工作已经提供了重要的见解，β-连环蛋白在细胞质中的稳定性的调节;然而，相对较少的是已知的机制，β-连环蛋白激活基因转录的核。使用遗传学方法，在人类结肠癌和果蝇中的研究已经将CDK 8鉴定为调节β-连环蛋白转录活性的结肠癌基因。这些会聚的观察结果为调节核β-连环蛋白活性提供了新的见解，并确定了β-连环蛋白驱动的恶性肿瘤的新治疗靶点。
The Wnt/β-catenin pathway plays an important role in the initiation in most, if not all, colon cancers. Prior work has provided important insights into the regulation of β-catenin stability in the cytoplasm; however, relatively little is known regarding the mechanism by which β-catenin activates gene transcription in the nucleus. Using genetic approaches, studies in human colon cancers and Drosophila have identified CDK8 as a colon cancer oncogene that regulates β-catenin transcriptional activity. These convergent observations provide new insights into the regulation of nuclear β-catenin activity and identify a novel therapeutic target for β-catenin-driven malignancies.