STAT3 Target Genes Relevant to Human Cancers.
STAT3 Target Genes Relevant to Human Cancers.
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DOI：
10.3390/cancers6020897
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发表时间：
2014-04-16
期刊：
影响因子：
5.2
通讯作者：
Lo HW
中科院分区：
文献类型：
--
作者：
Carpenter RL;Lo HW
自从其被发现以来，STAT 3转录因子已被广泛研究其作为转录调节因子的功能及其作为发育、正常生理学和许多疾病（包括癌症）的病理学的介体的作用。这些努力已经发现了一系列可以由STAT 3单独或与其他转录因子合作进行正向和负向调节的基因。通过调节基因表达，STAT 3已被证明在许多细胞过程中发挥关键作用，包括肿瘤发生、肿瘤生长和进展以及干细胞。有趣的是，最近的研究表明，STAT 3可能通过激活已知抑制肿瘤发生的基因的表达而表现为肿瘤抑制因子。其他证据表明，STAT 3可能会引起相反的影响，这取决于细胞环境和肿瘤类型。这些混合的结果表明需要更深入地了解STAT 3，包括其上游调控因子，平行转录辅助调控因子和下游靶基因。为了帮助满足这一未满足的需求，本次审查将主要集中在STAT 3下游靶基因，已被验证与肿瘤发生和/或人类癌症的恶性生物学。
Since its discovery, the STAT3 transcription factor has been extensively studied for its function as a transcriptional regulator and its role as a mediator of development, normal physiology, and pathology of many diseases, including cancers. These efforts have uncovered an array of genes that can be positively and negatively regulated by STAT3, alone and in cooperation with other transcription factors. Through regulating gene expression, STAT3 has been demonstrated to play a pivotal role in many cellular processes including oncogenesis, tumor growth and progression, and stemness. Interestingly, recent studies suggest that STAT3 may behave as a tumor suppressor by activating expression of genes known to inhibit tumorigenesis. Additional evidence suggested that STAT3 may elicit opposing effects depending on cellular context and tumor types. These mixed results signify the need for a deeper understanding of STAT3, including its upstream regulators, parallel transcription co-regulators, and downstream target genes. To help facilitate fulfilling this unmet need, this review will be primarily focused on STAT3 downstream target genes that have been validated to associate with tumorigenesis and/or malignant biology of human cancers.
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影响因子：
11.2
作者：
Chakraborty, Subhankar;Kaur, Sukhwinder;Guha, Sushovan;Batra, Surinder K.
通讯作者：
Batra, Surinder K.
影响因子：
56.9
作者：
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通讯作者：
Fu, XY
影响因子：
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作者：
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通讯作者：
Watson, CJ
影响因子：
4.8
作者：
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通讯作者：
Coqueret, O
影响因子：
8
作者：
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通讯作者：
Rizos, H.