Analysis of clonality and HPV infection in benign, hyperplastic, premalignant, and malignant lesions of the Vulvar mucosa
Analysis of clonality and HPV infection in benign, hyperplastic, premalignant, and malignant lesions of the Vulvar mucosa
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DOI：
10.1309/65mkpqt3e2bdm67e
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发表时间：
2004-08-01
影响因子：
3.5
通讯作者：
Murata, Y
中科院分区：
文献类型：
--
作者：
Ueda, Y;Enomoto, T;Murata, Y
为了阐明外阴癌的发病机制，我们研究了外阴上皮病中的克隆性和人乳头状瘤病毒(HPV)感染。9例浸润性肿瘤(鳞癌6例，基底细胞癌1例，恶性黑色素瘤2例)，15例外阴上皮内瘤变(VIN)，7例Paget病，2例硬化性苔藓(LS)，2例鳞状细胞增生症(SCH)，5例SCC和17例VIN均为高危型HPV。这些观察结果可能暗示LS和SCH的一组病例是肿瘤增殖的结果，类似于VINS，但与高危型HPV感染无关。在1例邻近病变合并VIN3的SCC中，这两例病变都显示出相同的X染色体失活模式和HPV-16以异体和整合的形式存在，提示高危型HPV整合引发的单克隆性扩张是HPV相关SCC发生的早期事件。
To elucidate the pathogenesis of vulvar carcinomas, we studied clonality and human papillomavirus (HPV) infection in vulvar epithelial diseases. Monoclonal composition was demonstrated in all 9 invasive tumors (squamous cell carcinoma [SCC], 6; basal cell carcinoma, 1; malignant melanoma, 2), 15 of 20 cases of vulvar intraepithelial neoplasia (VIN), 7 of 9 cases of Paget disease, 2 of 6 cases of lichen sclerosus (LS), and 2 of 3 cases of squamous cell hyperplasia (SCH); high-risk type HPV was revealed in 5 of 6 SCCs and 17 of 20 VINs. These observations might imply that a subset of cases of LS and SCH result from a neoplastic proliferation, similar to VINs but not related to infection with high-risk type HPV In 1 case of SCC with concurrent VIN 3 in an adjacent lesion, both lesions showed the same pattern of X chromosome inactivation and the presence of HPV-16 in episomal and integrated forms, suggesting that monoclonal expansion triggered by high-risk type HPV integration is an early event for carcinogenesis of HPV-associated SCC.